Efeitos do treinamento resistido e da Bowdichia virgilioides kunth na lesão nervosa periférica : avaliação do estresse oxidativo e da função

• Ano de defesa: 2020
• Autor(a) principal: Costa, Luana Santos
• Orientador(a): Martins, Felipe José Aidar
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Programa de Pós-Graduação: Pós-Graduação em Ciências Fisiológicas
• Palavras-chave em Português: Ciências fisiológicas; Lesão nervosa periférica; Treinamento resistido; Estresse oxidativo; Produtos naturais; Músculo esquelético
• Palavras-chave em Inglês: Peripheral nerve injury; Resistance training; Oxidative stress; Natural products; Skeletal muscle
• Área do conhecimento CNPq: CIENCIAS BIOLOGICAS::FISIOLOGIA
• Link de acesso: http://ri.ufs.br/jspui/handle/riufs/15834

Effect of Resistance Training and Bowdichia virgilioides Kunth on Peripheral Nerve Injury: Evaluation of Oxidative Stress and Skeletal Muscle Function. Luana Santos Costa. São Cristóvão/SE, 2020. Peripheral Nerve Injury (PNI) is a neuromuscular disorder that promotes impairment of skeletal muscle function such as loss of muscle mass and decreased functional capacity. Studies prove that consequences of PNI are associated with Oxidative Stress (OE). Currently there are several forms of treatment for PNI, which in short culminate in unsatisfactory results. Resistance Training (RT) has shown a protective effect on PNI and its simultaneous use with other therapeutic techniques, such as phytotherapy, seems to lead to better results. Bowdichia virgilioides Kunth is a tree whose components have proven antioxidant action and associated with RT is able to promote a better antioxidant response than its use alone. This work aimed to analyze the effects of a RT and Hydroethanolic Extract (EHE) program of Bowdichia virgilioides stem interbark under OE markers and skeletal muscle function in Wistar rats submitted to PNI. The induction of the lesion was performed from compression of the right sciatic nerve. Sixty 3-month-old male rats were divided into 6 groups (n=10 per group): animals that did not undergo any intervention (C); sedentary animals that had the sciatic nerve exposed, but did not suffer injury (S); sedentary animals that received a vehicle and suffered injury (L); trained animals that received a vehicle and suffered injury (LT); animals that suffered injury and received EHE. (LE); and animals that suffered injury, performed the RT protocol and received the EHE (LTE). The RT consisted of the ladder climbing method, while the EHE was administered orally at a dose of 200 mg/kg. The interventions were performed for a period of 21 days. Levels of MDA and SH in blood, right gastrocnemius muscle, brain and liver were evaluated, in addition to the quantification of serum CK, LDH, AST and ALT. In addition, temperature was also measured through thermography, verified weight of the right gastrocnemius muscle and grip strength of the hind legs. The use of EHE or RT alone were also able to provoke a good response against OE markers. The exercise protocol, EHE intake and concomitant use of both decreased temperature at the site of the injury. The use of EHE alone or associated with RT promoted a decrease in CK, LDH and AST levels, while ALT levels were similar in the six groups. However, only the group that performed the exercise protocol associated with EHE obtained muscle gain and better motor response in neuropathy. In view of the above, it was evidenced that the RT associated with the ingestion of the EHE of the Bowdichia virgiloides Kunth entrecasca causes a decrease in OE, which supposedly reflects a better functional capacity and greater muscle mass gain in PNI.