Avaliação da dor pós-operatória e aspectos toxicológicos do uso de dipirona e tramadol em gatas

• Ano de defesa: 2018
• Autor(a) principal: Teixeira, Luciana Gonçalves
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Santa Maria; Brasil; Medicina Veterinária; UFSM; Programa de Pós-Graduação em Medicina Veterinária; Centro de Ciências Rurais
• Palavras-chave em Português: Gatos; Dipirona; Tramadol; Efeitos hematológicos; Oxidação de eritrócitos; Cats; Metamizole tramadol; Hematological effects; Erythrocyte oxidation; CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA
• Link de acesso: http://repositorio.ufsm.br/handle/1/14089

Metamizole is a non-opioid analgesic drug widely used in feline medicine. However, the recommended doses for this species are variable as this drug is believed to cause adverse effects. The aim of this study was to evaluate the effects of metamizole and tramadol used for five consecutive days on postoperative pain, hematological and biochemical parameters, and oxidative status markers on erythrocytes. Twenty-eight adult female cats were considered healthy were enrolled in the study. After 3 days of adaptation, cats were submitted to elective ovariohysterectomy by celiotomy and randomly allocated to 4 groups of 7 animals each, according to the postoperative treatment administered for 5 days: Control (1 ml IV, 8/ 8h), DIP1 (metamizole IV, 24h), DIP2 (metamizole IV, 12/ 12h) and DIP3 (metamizole IV, 8/ 8h). All animals also received tramadol (2 mg/kg 8/8h). Postoperative pain was evaluated using the Visual Analogue (EVA), multidimensional UNESP (EUNESP) and Glasgow Composite pain scales for cats (EGLASGOW) on the third day of adaptation (baseline) and 3, 6, 12, 24, 36 and 48 hours after extubation. Venous blood was collected daily for 5 days, and on the 10th day after surgery, to determine the percentage of Heinz body (HB) and complete blood count. Serum creatinine (C), urea (U), aspartate aminotransferase (AST) and albumin were evaluated pre-surgery and on 5th and 10th days after the procedure; superoxide dismutase (SOD), catalase (CAT), myeloperoxidase (MPO) and lipoperoxidation were evaluated before surgery and on the 3rd, 5th, and 10th, days after the procedure. Stress oxidative parameters were also assessed on 3rd day after surgery. Control group presented higher pain scores than the DIP3 by EUNESP, and higher than DIP2 and DIP3 by EVA 3 hours after surgery. Rescue analgesia was performed at 3 hours postoperative in control and DIP1 groups and at 6 hours after surgery in one animal in DIP2. The activity of SOD, CAT and MPO was similar between groups, except on day 5, when MPO was significantly more active in DIP2 than DIP3. Lipoperoxidation was similar among the treatments and the control group. The concentration of platelets, leukocytes, mean corpuscular volume, mean corpuscular hemoglobin concentration remained constant throughout the study period and similar among the groups at the times evaluated. Although the percentage of Heinz bodies had not been altered over time in each group, DIP1 presented a percentage of HB significantly higher than the control and lower than DIP2 and DIP3 on the 10th day. C, U, AST and albumin were similar among groups and times evaluated. The results obtained in this work suggest that the administration of metamizole is well tolerated in cats at the dose of 25 mg/ kg even when used in combination with tramadol, allowing to conclude that its use was safe in healthy cats submitted to elective surgery, even when administered every 8 hours.