Cloridrato de amiodarona – estudo comparativo de metodologias de análise de matéria-prima
Ano de defesa: | 2004 |
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Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | |
Tipo de documento: | Dissertação |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Universidade Federal de Santa Maria
Brasil Desenvolvimento e Avaliação de Produtos Farmacêuticos UFSM Programa de Pós-Graduação em Ciência e Tecnologia Farmacêuticas Centro de Ciências da Saúde |
Programa de Pós-Graduação: |
Não Informado pela instituição
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Departamento: |
Não Informado pela instituição
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País: |
Não Informado pela instituição
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Palavras-chave em Português: | |
Link de acesso: | http://repositorio.ufsm.br/handle/1/23896 |
Resumo: | The purpose of the author of the present work was to study the differences among the methodologies found in the literature taking into account only the description in the official codes of the volumetric titulation in acquous means to the determination of amiodarone chloridrate. The objective was to determine this substance in other types of samples and develop them in order to allow their employment in the identification and quantitative determination of the substance in study, as well as to provide subsidies in the form of methods of analysis to be incorporated in the Brazilian Pharmacopoeia. All the methodologies were studied, modified and validated according to the international norms. The methods developed presented linearity, precision and accuracy. They also showed equivalence when submitted to statistics studies, by means of variance analysis, according to the proposed to be officialized by the Brazilian Pharmacopoeia. |