Papel do sistema purinérgico e dos receptores de potencial transitório vaniloide 1 (TRPV 1) na dor muscular tardia após exercício excêntrico em ratos

• Ano de defesa: 2014
• Autor(a) principal: Retamoso, Leandro Thies
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Santa Maria; BR; Educação Física; UFSM; Programa de Pós-Graduação em Educação Física
• Palavras-chave em Português: Xantina oxidase; Downhill; Purinas; Xanthine oxidase; Purines; CNPQ::CIENCIAS DA SAUDE::EDUCACAO FISICA
• Link de acesso: http://repositorio.ufsm.br/handle/1/6715

Chronic exercise has been recommended as a strategy for preventing several diseases associated with lifestyle such as heart disease, hypertension, osteoporosis and type II diabetes. Although regular physical exercise has benefits for health, all sports practitioners, and even sedentary people, have already feel delayed onset muscle soreness (DOMS) once, characterized by discomfort in skeletal muscle. As the most DOMS generator, acute eccentric exercise induce fatigue, strength reduction and performance impairment. Despite some researches demonstrating reactive oxygen species (ROS) in this context, there are few information about purine degradation as well as transient receptor potential vanilloid 1 (TRPV1) on DOMS development. In this context, animals performed a downhill running test (eccentric exercise) on treadmill until exhaustion for histologic evaluation, mechanical allodynea, strength force test and biochemical analysis. The results showed an increase in mechanical allodynea and ADP, AMP, uric acid and TRPV1 immunoreactivity levels. In conclusion, the results support the contribution of ROS and the participation of purine and TRPV1 on delayed onset muscle soreness.