Novos polímeros a base de ácido glicerofosfórico/beta-ciclodextrina reticulado com ligações uretânicas : preparação e incorporação de ciprofloxacina

• Ano de defesa: 2017
• Autor(a) principal: Moreira, Mirna Pereira
• Orientador(a): Gimenez, Iara de Fátima
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Sergipe
• Programa de Pós-Graduação: Pós-Graduação em Ciência e Engenharia de Materiais
• País: Brasil
• Palavras-chave em Português: Engenharia de materiais; Polímeros; Poliuretanas; Ciprofloxacina; Farmacologia; Poliuretano ternário; β-ciclodextrina; β-glicerofosfato; Complexo de inclusão; Fármaco; Ciprofloxacin
• Palavras-chave em Inglês: Ternary polyurethane; β -cyclodextrin; β -glycerophosphate; Inclusion complex; Drug delivery
• Área do conhecimento CNPq: ENGENHARIAS::ENGENHARIA DE MATERIAIS E METALURGICA
• Link de acesso: https://ri.ufs.br/handle/riufs/3473

Synthesis of ternary polyurethanes (PUs) from hexamethylenediisocyanate, β- cyclodextrin and β-glycerophosphate (acid and calcium salt) was studied varying synthesis parameters such as monomer proportion, heating method (reflux and microwave), and catalyst amount. Favorable conditions were provided by microwave irradiation and use of β-glycerophosphoric acid although the results suggest that it is possible to obtain ternary PUs with the calcium salt. FTIR data indicated the existence of secondary urea linkages. After characterization of ternary PUs by FTIR spectroscopy, XRD and thermal analysis, as well as evidences that the cyclodextrin cavities remained active toward inclusion of guest molecules, the possibility of inclusion of the antibiotic ciprofloxacin was evaluated. Absence of ciprofloxacin melting peak in DSC curves indicated that it is molecularly dispersed within the polymer, possibly included in the cyclodextrin. In vitro release experiments suggested additional non-inclusion interactions, showing also that the use of dialysis membranes may mask the actual release profile.