Análise do reparo ósseo com alendronato de sódio associado ao osso bovino liofilizado (bio-oss®): estudo radiomicrográfico em calvária de coelhos.

• Ano de defesa: 2013
• Autor(a) principal: Rocha, Stela Maris Wanderley
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal da Paraí­ba; BR; Odontologia; Programa de Pós Graduação em Odontologia; UFPB
• Palavras-chave em Português: Odontologia; Tecido ósseo; Bone and Bones; Alendronate; Bone Substitutes; Rabbit; CNPQ::CIENCIAS DA SAUDE::ODONTOLOGIA
• Link de acesso: https://repositorio.ufpb.br/jspui/handle/tede/6648

This study aims to evaluate the effect of 0.5% (5mg/ml) and 1% (10mg/ml) alendronate sodium (ALN) associated or not with lyophilized bovine bone (Bio-Oss®) on the repair of calvaria bone defects in rabbits. Two bony defects, 10mm diameter circular, were created in 40 male New Zealand white rabbits. The animals were randomized into five (n = 8) groups: GI = Bio-Oss®; GII = Bio-Oss® + ALN 0.5%; GIII = Bio-Oss® + ALN 1%; GIV = ALN 0. 5%; GV = ALN 1%. The left defect was filled with the corresponding substance of each experimental group and the right defect was filled with autogenous blood clot (control). All cavities were lined and covered with a biological membrane. The animals were euthanized 30 and 60 days after craniotomy. The percentage of new bone formation was assessed by microradiographic analysis of calvaria. The images obtained were analyzed using the public domain program Image J®, to assess quantitatively the percentage of bone repair. The values obtained were analyzed using the software SPSS® Statistics, using descriptive statistics (mean, standard deviation and confidence intervals) and inferential ("t" - Student and ANOVA/Tukey). The intragroup results showed that in GI, GII and GIII the percentage of bone repair was significantly higher in the experimental side compared to their respective controls; and was not statistically difference in GIV and GV groups, between experimental and controls sides. The intergroup results showed the following percentage of repair at 30 days: GI = 61.91% (± 10.61), GII = 80.39 (± 8.68), GIII = 81.60% (± 5.42), GIV = 48.45% (± 6.54), GV = 41.45% (± 8.98) and at 60 days: GI = 83.23% (± 14.43), GII = 98.72% (± 2.54), GIII = 92.66% (± 9.22), GIV = 50.18% ( ± 3.03), GV = 37.46% (± 6.26). It is concluded that the addition of alendronate in concentrations of 0.5 and 1%, to lyophilized bovine bone, accelerate the process of bone repair, being more significant in lower concentration. The use of ALN alone delayed the process of bone repair, but without statistical significance.