Efeitos da suplementação de zinco e do treinamento físico sobre o controle de peso e o metabolismo glicêmico em ratas ovariectomizadas

• Ano de defesa: 2012
• Autor(a) principal: Rodrigues, Anderson Ferreira
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal da Paraí­ba; Brasil; Ciências da Nutrição; Programa de Pós-Graduação em Ciências da Nutrição; UFPB
• Palavras-chave em Português: Envelhecimento; Metabolismo; Nutrição; Fisiologia do exercício; Treinamento de resistência; Aging; Metabolism; Nutrition; Exercise physiology; Resistance training; CIENCIAS DA SAUDE::NUTRICAO
• Link de acesso: https://repositorio.ufpb.br/jspui/handle/tede/4280

It is common to observe menopausal metabolic disorders that lead to weight gain and changes in glycemic control. Physical activity and zinc supplementation have been suggested as interventions to prevent weight gain and glucose metabolism disorders. Thus, this study aims to assess the effects of physical training and zinc supplementation on carbohydrate metabolism and weight control in ovariectomized rats. We used 60 Wistar divided into five groups: Sham (S), ovariectomized control (OX-C), ovariectomized + zinc supplementation (OX-Z), ovariectomized + physical training (OX-TF) and ovariectomized + zinc supplementation + physical training (OX-ZTF). Groups Z and ZTF received daily zinc supplementation (25mg/Kg body weight) in the form of oral ZnSO4.7H2O for eight weeks. Groups OX-TF and OX-ZTF performed a protocol of water jumps with gradual load increase three times a week for nine weeks. The parameters were analyzed using the paired and non-paired Student t test and one-way and two-way ANOVA with post hoc Newman-Keuls and MannWhitney test for nonparametric data (p <0.05). The ovariectomized control group (OX-C) showed higher feed intake and body weight compared to control group (Sham) (p <0.05). The OX-Z groups (16.20 ± 1.70g), OX-TF (17.28 ± 0.81g) and OX-ZTF (17.24 ± 1.71g) had lower food consumption, differently from the group OX -C (18.03 ± 0.98g), which had more value compared to the Sham group (16.39 ± 0.92g). Body weight was also higher in group OX-C (303 ± 33.89g) compared to Sham (245.2 ± 38.91 g) and zinc supplementation was the only intervention able to promote body weight lower in the group OX-Z (262.2 ± 24.16g). As for insulin, its concentration was significantly higher in group OX-ZTF (5.66 ± 0.99μIU / mL) compared to the group OX-C (3.40 ± 1.27 μIU / mL). Glycemia of the group X-Z (92.67 ± 7.28 mg/dL) was lower than the Sham group (122.0 ± 17.09 mg/dL). It is concluded that zinc supplementation was responsible for lower food consumption, which is related to maintenance of body weight. Furthermore, lower glucose levels were found in the zinc supplementation group, which may represent a better peripheral glucose uptake. The combination of zinc supplementation and physical training led to higher insulin concentration and physical performance, possibly due to the anabolic effects of this hormone on muscle hypertrophy.