Detalhes bibliográficos
| Ano de defesa: |
2016 |
| Autor(a) principal: |
Baú, Carlos Eduardo Giuliani |
| Orientador(a): |
Simão, Éder Maiquel |
| Banca de defesa: |
Rybarczyk Filho, José Luiz,
Silva, Solange Cristina da |
| Tipo de documento: |
Dissertação
|
| Tipo de acesso: |
Acesso aberto |
| Idioma: |
por |
| Instituição de defesa: |
Centro Universitário Franciscano
|
| Programa de Pós-Graduação: |
Programa de Pós-Graduação em Nanociências
|
| Departamento: |
Biociências e Nanomateriais
|
| País: |
Brasil
|
| Palavras-chave em Português: |
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| Palavras-chave em Inglês: |
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| Área do conhecimento CNPq: |
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| Link de acesso: |
http://www.tede.universidadefranciscana.edu.br:8080/handle/UFN-BDTD/546
|
Resumo: |
Microarrays are instruments for measurement and analysis of several genes simultaneously, one of its uses is the verification of distinguishing gene expression in diseases. This work aims to verify the distinction between the expression of proteins in glioblastoma, using the data collected from the Gene Expression Omnibus database, because this cancer is characterized as of high incidence and it’s difficult to treat. After computational statistical analysis, it was found that the genes TNIP2, TOLLIP, IKBKB, PSMF1, RASGRF2, NEFL, DNM1, CDC42, YES1, C1S and PAK1, are differentially expressed in the pathways of the immune system, however, only the genes TNIP2, TOLLIP, IKBKB, are part of the NF-KB pathway, known to fight inflammation. The expectation of this work, and it´s future studies, hope to demonstrate different expressed genes in the immune system and thus help to better understand the development of the disease and its treatment, by nanoencapsulation of temozolimoda, a drug used along with radiotherapy. |
