Detalhes bibliográficos
| Ano de defesa: |
2024 |
| Autor(a) principal: |
Fontana , Tuyla |
| Orientador(a): |
Machado, Alencar Kolinski |
| Banca de defesa: |
Fagan , Solange Binotto,
Pesarico , Ana Paula |
| Tipo de documento: |
Dissertação
|
| Tipo de acesso: |
Acesso aberto |
| Idioma: |
por |
| Instituição de defesa: |
Universidade Franciscana
|
| Programa de Pós-Graduação: |
Programa de Pós-Graduação em Nanociências
|
| Departamento: |
Biociências e Nanomateriais
|
| País: |
Brasil
|
| Palavras-chave em Português: |
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| Palavras-chave em Inglês: |
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| Área do conhecimento CNPq: |
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| Link de acesso: |
http://www.tede.universidadefranciscana.edu.br:8080/handle/UFN-BDTD/1283
|
Resumo: |
Neuropsychiatric disorders, such as depression, pose a global challenge to public health due to the incomplete understanding of their causes and pathophysiological mechanisms, which hinders the effectiveness of available treatments. Chronic administration of corticosterone is widely recognized as an experimental model for inducing depressive behavior in animals, providing a valuable tool for studying this condition. Recently, the therapeutic potential of natural products, such as açaí (Euterpe oleracea Mart), has been investigated due to their neuroprotective and anti-neuroinflammatory effects. However, its efficacy as an antidepressant in models of chronic exposure to glucocorticoids still lacks robust scientific evidence. Therefore, this study aims to evaluate the effects of hydroalcoholic extract of açaí, both in free and nanostructured form, in in vitro and in vivo models of corticosterone induced depression. Using BV-2 cell line cells and male Swiss adult mice exposed to corticosterone, behavioral tests and biochemical analyses were performed to assess the effects of açaí extract treatment on corticosterone-induced alterations. Preliminary results indicate that açaí nanoemulsion may reverse depressive symptoms in mice, suggesting promising therapeutic potential with lower toxicity compared to conventional drugs. These findings provide a solid foundation for the continuation and deepening of this study, aiming for a more comprehensive understanding of the therapeutic effects of free and nanostructured açaí in neuropsychiatric disorders. |
