Detalhes bibliográficos
| Ano de defesa: |
2015 |
| Autor(a) principal: |
Rodrigues, Luiz Henrique Rauber |
| Orientador(a): |
Simão, Éder Maiquel |
| Banca de defesa: |
Werhli, Adriando Velasque,
Rossato, Jussane |
| Tipo de documento: |
Dissertação
|
| Tipo de acesso: |
Acesso aberto |
| Idioma: |
por |
| Instituição de defesa: |
Centro Universitário Franciscano
|
| Programa de Pós-Graduação: |
Programa de Pós-Graduação em Nanociências
|
| Departamento: |
Biociências e Nanomateriais
|
| País: |
Brasil
|
| Palavras-chave em Português: |
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| Palavras-chave em Inglês: |
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| Área do conhecimento CNPq: |
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| Link de acesso: |
http://www.tede.universidadefranciscana.edu.br:8080/handle/UFN-BDTD/537
|
Resumo: |
Dysplasia such as cancer can be identified by expression patterns involving mechanisms genome maintenance pathways (GMM). Activation pathways involved in the cell cycle (CC), in the DNA damage response (DDR) and apoptosis (APO), significantly contribute to tumor development. In previous studies, it was found that the precancerous activation process there is an anticancer barrier which is responsible for prevention of tumor progression. The identification of more expressed genes during activation of the anti-cancer barrier, with interactions associated GMM, is a complementary study of the way to evolution of cancer. In this work, the objective was investigate the anti-cancer barrier activation in pre-cancer and cancer, in tissues of adrenal gland, colon, pancreas and thyroid follicles, using networks of interaction between proteins. To describe this barrier was proposed modeling the interaction networks between proteins GMM routes with Cytoscape software. The results obtained with the most important genes in expression and quantity of interactions were compared with the results of previous publications and reconfirmed the relevance of genes CDKN1A, CHEK1, ATR, P53, MRE11A, BRCA1 and XRCC4. Through analysis allowed the identification of other genes, complementary to previous studies, as SKP2, CCNO, FADD, RAD50, NBN, BIRC3, CDK2 and XRCC6. These genes are associated with and complement activation studies of anti-cancer barrier. These considerations emphasize that it is important to observe all systemic biological context, soaking, as in nanoscience where the study makes sense to take into account the interactions. Analyses of interactions enable the development of future work, for example, treatment with drugs nanocapsules, activating or inhibitory acting proteins such as interlocking routes GMM, or nanosensors to monitor the development of cancer. |
