Detalhes bibliográficos
| Ano de defesa: |
2022 |
| Autor(a) principal: |
Bruckmann, Franciele da Silva |
| Orientador(a): |
Rhoden , Cristiano Rodrigo Bohn |
| Banca de defesa: |
Junior , Tito Roberto Sant’Anna Cadaval,
Santos, Cláudia Lange dos |
| Tipo de documento: |
Dissertação
|
| Tipo de acesso: |
Acesso aberto |
| Idioma: |
por |
| Instituição de defesa: |
Universidade Franciscana
|
| Programa de Pós-Graduação: |
Programa de Pós-Graduação em Nanociências
|
| Departamento: |
Biociências e Nanomateriais
|
| País: |
Brasil
|
| Palavras-chave em Português: |
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| Palavras-chave em Inglês: |
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| Área do conhecimento CNPq: |
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| Link de acesso: |
http://www.tede.universidadefranciscana.edu.br:8080/handle/UFN-BDTD/1105
|
Resumo: |
Environmental contamination by emerging pollutants is a worldwide problem due to their bioaccumulation, biopersistence, low degradability, and numerous negative effects on aquatic life, microbiota, animals, and human health. In this sense, many of these compounds are not fully removed from wastewater treatment systems by conventional techniques due to low concentration (ng L-1), complex chemical structure, and hydrosolubility, requiring te development of alternative and effective methods. Adsorption is a tertiary process and widely explored method considering its excellent performance in organic and inorganic pollutants removal, easy operability, low cost, and energy requirement. Thus, this work aimed to synthesize and characterize magnetic nanocomposites (GO·Fe3O4 and CS·Fe3O4) and evaluate the effect of magnetite incorporation into materials on the tetracycline and methotrexate adsorption, the influence in adsorption mechanisms via theoretical-experimental study, as well as the in vitro cytotoxicity of adsorbent/adsorbate complex. Magnetic adsorbents were effectively characterized (FTIR, XRD, Raman, Zeta potential, VSM, BET, and SEM-EDS). Regarding adsorption studies, the maximum adsorption capacity and removal percentage of tetracycline (GO·Fe3O4 1:1) and methotrexate (CS·Fe3O4 1:1) were (531.93 mg g-1and 81.85%) and (285.92 mg g-1and 97.71%), respectively. The adsorbents showed excellent regeneration and reuse capacity, maintaining the magnetic behavior and removal efficiency above 60%, even after five cycles of adsorption-desorption. Corroborating with theoretical studies, the experimental data revealed a chemisorption behavior for both studies. On the other hand, the in vitro biological study showed that the adsorbent/adsorbate complex CS·Fe3O4 1:1-MTX demonstrate pronounced activity than the free drug and higher cytotoxicity against human melanoma tumor cells . Finally, it was possible to conclude that magnetic adsorbents prove to be potential materials for removing drugs from the aqueous medium, avoiding the filtration and centrifugation steps. At the same time, the cytotoxicity assays revealed the safety of the complex, inspiring new studies for drug reposition. |
