DERIVADOS DA GLUCOSAMINA: SÍNTESE E ATIVIDADE BIOLÓGICA

• Ano de defesa: 2010
• Autor(a) principal: Appelt, Helmoz Roseiniaim
• Orientador(a): Appelt, Helmoz Roseniaim
• Banca de defesa: Alves, Marta Palma, Martins, Tales Leandro Costa
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Centro Universitário Franciscano
• Programa de Pós-Graduação: Programa de Pós-Graduação em Nanociências
• Departamento: Biociências e Nanomateriais
• País: Brasil
• Palavras-chave em Português: Glucosamina, atividade antimicrobiana, bases de Schiff, disco-difusão, microduição.
• Palavras-chave em Inglês: Glucosamine, antimicrobial activity, Schiff base, difusion disc, microduition
• Área do conhecimento CNPq: Biociências e Nanomateriais
• Link de acesso: http://www.tede.universidadefranciscana.edu.br:8080/handle/UFN-BDTD/475

In the present work, several compounds derived from monosacharide D-Glucosamine were synthetized. These compounds were used successfully against gram-positive and gram-negative microorganisms. In the synthesis of compounds, classical methods in organic chemistry were used. All steps of synthesis are shown in the Scheme below. The products were readily prepared from D-Glucosamine in few easy steps. In the first step, we have obtained he imine derivatives 2a or 2b. The resultant imines were protected in the OH groups at C1, C3, C4 and C6 positions with acetyl group. Selective desprotection of C2 aminogroup and coupling with cmnamic acid fford compound 5. All compounds were tested as antimicrobial agents against gram-positive and gram-negative microorganisms. Best results were obtained when compound 2b was used.