Avaliação laboratorial da hemostasia e a relação da carga parasitária com a apresentação clínico - laboratorial de cães com leishmaniose visceral no município de Cuiabá

• Ano de defesa: 2012
• Autor(a) principal: Torres, Mariana de Medeiros
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Mato Grosso; Brasil; Faculdade de Agronomia, Medicina Veterinária e Zootecnia (FAMEVZ); UFMT CUC - Cuiabá; Programa de Pós-Graduação em Ciências Veterinárias
• Palavras-chave em Português: Cão; Coagulação; Fígado; Hemostasia; Leishmaniose; Rim; CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA; Coagulation; Dogs; Hemostasis; Kidney; Leishmaniasis; Liver
• Link de acesso: http://ri.ufmt.br/handle/1/1439

Hemostatic disorders in visceral leishmaniasis are triggered by immune-mediated processes, resulting in inflammation and hepatic and renal lesions. The study describe the alterations in hemostasis and relate them to clinical aspects and histopatological findings. In the canine visceral leishmaniasis group (GLVC) thrombocytopenia was observed in 14 dogs (51,85%), with no correlation between the increase in APTT and hepatic lesion (r= -0,20). Eleven dogs with hepatic lesions predominantly periportal mononuclear hepatitis mild multifocal (29,62%) and in kidneys mononuclear interstitial nephritis predominated in varying degrees (59,25%), membranous glomerulonephritis (18,51%), interstitial fibrosis and periglomerular (18,51%). Comparing the parasite load of kidneys (P=0,48) and liver (P= 1,0) no significant values was observed. Histopathological findings in kidney and alterations in primary hemostasis are consistent findings in visceral leishmaniasis, while the hepatic damage can extend the results on secondary hemostasis tests