Estudo da associação do polimorfismo rs7903146 do gene TCF7L2 com a doença hepática gordurosa não alcoólica em mulheres obesas e diabéticas

Detalhes bibliográficos
Ano de defesa: 2013
Autor(a) principal: Scholze, Ana Flávia Amorim
Orientador(a): Não Informado pela instituição
Banca de defesa: Não Informado pela instituição
Tipo de documento: Dissertação
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Universidade Federal de Mato Grosso
Brasil
Faculdade de Nutrição (FANUT)
UFMT CUC - Cuiabá
Programa de Pós-Graduação em Nutrição, Alimentos e Metabolismo
Programa de Pós-Graduação: Não Informado pela instituição
Departamento: Não Informado pela instituição
País: Não Informado pela instituição
Palavras-chave em Português:
Link de acesso: http://ri.ufmt.br/handle/1/1754
Resumo: Introduction: Single nucleotide polymorphisms (SNPs) in TCF7L2 have been reported as possible risk factors for NAFLD and a number of metabolic disorders involving glucose homeostasis and lipoproteins. Method: We investigate the association between rs7903146 TCF7L2 gene polymorphism and NAFLD diabetic obese women. According to liver steatosis they were divided in NAFLD and Non-NAFLD. Results: The NAFLD group had higher waist circumference, body fat percentage, fasting and postprandial insulin, HOMA-β, triacylglycerols, ALT, AST, GGT, alkaline phosphatase and TNF-α compared to Non-NAFLD group. QUICKI, HDL, adiponectin and interleukin-6 were lower in NAFLD patients. No association was observed between rs7903146 polymorphism and NAFLD when analyzed isolated, but there was an interaction when this polymorphism was related with NAFLD and diabetes on the following parameters: fasting insulin, HOMA-β, QUICKI, triacylglycerols and TNF-α. The subcutaneous/visceral fat ratio was lower in patients NAFLD diabetics with TT genotype. There was a negative correlation between subcutaneous/visceral fat ratio and plasma triacylglycerols in individuals with at least one T allele. Conclusion: These results demonstrate that TCF7L2 rs7903146 polymorphism can influence some risk factors that predispose to NAFLD in diabetic obese women related to an increased lipid serum and visceral fat accumulation.