Estudo clínico genético sobre a displasia coxofemoral em cães e sua associação ao polimorfismos de nucleotídeos simples (SNPs) candidatos

• Ano de defesa: 2024
• Autor(a) principal: Conceição, Thais Figueiredo
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Mato Grosso; Brasil; Faculdade de Medicina Veterinária (FAVET); UFMT CUC - Cuiabá; Programa de Pós-Graduação em Ciências Veterinárias
• Palavras-chave em Português: Displasia coxofemoral em cães; Polimorfismos de nucleotídeo simples (SNPs); Análises genéticas; Radiografias caninas; CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA; Canine hip dysplasia; Single nucleotide polymorphisms (SNPs); Genetic analysis; Canine radiographs
• Link de acesso: http://ri.ufmt.br/handle/1/6510

Hip dysplasia (CD), characterized by abnormal laxity of the hip joint, predominantly affects medium and large dogs. This study aimed to investigate the incidence of CD through genetic analysis, using three single nucleotide polymorphisms (SNPs) associated with the disease in other breeds. This genetic approach seeks to enhance understanding of the genetic basis underlying CHD, with significant implications for early diagnosis and the development of more effective management and treatment strategies. Whole blood samples were collected from 61 individuals, processed for DNA extraction, polymerase chain reaction (PCR) amplification, and sequencing of the BICF2G630227898, BICF2G630339806, and BICF2S2459425 SNP regions. The results revealed that 96% of individuals had the BICF2G630227898 SNP, while 62% and 34% had the BICF2G630339806 and BICF2S2459425 SNPs, respectively. These findings contribute to a deeper understanding of the genetic predisposition to hip dysplasia, emphasizing the need for additional research to identify polymorphisms associated with the condition and to develop accurate diagnoses based on genetic analysis.