Comparação dos efeitos da sedação consciente mínima realizada com extrato fixo de valeriana-lúpulo e midazolam na exodontia de terceiros molares inferiores retidos

• Ano de defesa: 2022
• Autor(a) principal: Oliveira, Renata Lanzoni de
• Orientador(a): Bastos, Paulo Roberto Haidamus de Oliveira
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Fundação Universidade Federal de Mato Grosso do Sul
• País: Brasil
• Palavras-chave em Português: Cirurgia e Traumatologia Buco-Maxilo-Facial; Sedação Consciente; Exodontia; Anestesiologia; Sedativos; Analgésicos; Medicamentos Fitoterápicos; Oral and Maxillofacial Surgery; Conscious Sedation; Tooth Extraction; Anesthesiology; Sedatives; Analgesics; Herbal Medicines
• Link de acesso: https://repositorio.ufms.br/handle/123456789/5360

This prospective, split-mouth, triple-blind, randomized clinical trial aimed to analyze the comparison of the Valerian-Hop fixed extract and midazolam effects in minimal conscious sedation through the analysis of postoperative pain, anxiety, postoperative pain, vital signs and anterograde amnesia, in individuals who underwent impacted lower third molars extraction. The study was completed by 23 individuals aged between 18 and 25 years, of both sexes, with ASA I surgical risk classification and with impacted lower third molars positioned in a similar way bilaterally. The surgical interventions were performed by a single specialist in oral and maxillofacial surgery and traumatology, in two different sessions, with an interval of 21 days between them. Before all surgeries, each participant received an 8 mg dexamethasone capsule. Forty-five minutes before surgery, they randomly received, orally, 1 capsule of valerian 500 mg – Hops 120 mg or midazolam 15 mg for each side to be operated. Each participant received 12 paracetamol 750mg tablets to take, when necessary, postoperatively. The Modified Dental Anxiety Scale (MDAS) was applied at three moments (preoperative, before the first and second surgery), vital signs were analyzed in 7 moments, the sedation level was also observed and the participant took a visual analogue pain scale to answer at home, in addition to a questionnaire for the anterograde amnesia analysis. Our results showed that there was no significant difference between midazolam and Valerian-Hop considering anxiety score, in the three analyzed moments. The sedation level was higher with midazolam. Midazolam appeared to control postoperative pain better than valerian-hops. There was no statistically significant difference between treatments and the pain peak. There was also no association between the two treatments regarding your consumption and the 1st escape analgesics intake. The systolic and diastolic blood pressure values were higher when using Valerian-Hop, although the values were within the clinical normal range. Heart rate had higher values when we used midazolam only 45 minutes after administration, with no significant difference at other times. We did not find statistically significant results regarding oxygen saturation. Midazolam showed better results in relation to anterograde amnesia. We conclude that Valerian-Hops was able to establish comfort, few hemodynamic changes and few side effects, being an alternative to be used with anxious patients in preoperative period who need lower third molar extraction.