Propriedades antiartrítica e antinociceptiva do óleo essencial de ylang-ylang (Cananga odorata) em modelos experimentais

• Ano de defesa: 2022
• Autor(a) principal: Paloma Kênia de Moraes Berenguel Lossavaro
• Orientador(a): Saulo Euclides Silva Filho
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Fundação Universidade Federal de Mato Grosso do Sul
• País: Brasil
• Palavras-chave em Português: Propriedades antiartrítica e antinociceptiva do óleo essencial de ylang-ylang (Cananga odorata) em modelos experimentais
• Link de acesso: https://repositorio.ufms.br/handle/123456789/5569

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease, characterized by a chronic inflammatory process in the joints. Treatment involves the use of many classes of drugs, such as anti-inflammatories, but the use of anti-inflammatories becomes limited due to the side effects that these drugs cause. Ylang-ylang (Cananga odorata) is a medicinal plant of the Annonaceae family, with anti-inflammatory activity already described in the literature, in models of acute inflammation. The aim of this study was to evaluate the activity of ylang-ylang essential oil (Cananga odorata) (YEO) in an arthritis experimental model, persistent inflammation and nociception in rodents. Oral treatment with YEO at doses of 100 and 200 mg/kg reduced leukocyte infiltration in the joint cavity of mice submitted to zymosan-induced arthritis, at 6 hours and 7 days after arthritis induction. At these same doses, treatment with YEO reduced the formation of joint edema at 4 and 6 hours after arthritis induction and, only at a dose of 200 mg/kg, treatment with YEO reduced mechanical hyperalgesia at 3 and 4 hours. hours after arthritis induction. At a dose of 200 mg/kg, treatment with YEO reduced interleukin-6 (IL-6) production 6 hours after arthritis induction. At 7 days after arthritis induction, histological analysis demonstrated that treatment with YEO at a dose of 200 mg/kg reduced cartilage damage in arthritic mice. At a dose of 200 mg/kg, treatment with YEO reduced edema formation and mechanical hyperalgesia in a model of persistent inflammation induced by Complete Freud's Adjuvant (CFA) in mice. Treatment with YEO, at a dose of 200 mg/kg, reduced the nociceptive response in experimental models of nociception induced by acetic acid and formalin. In conclusion, YEO inhibited inflammatory parameters in an experimental arthritis model, showed activity in a model of persistent inflammation induced by CFA and nociceptive response in rodents. YEO may be a potential natural product for the treatment of lesions resulting from chronic inflammatory diseases, such as RA.