Classificação imunofenotípica do linfoma de gatos domésticos e sua correlação com o vírus da leucemia felina

Detalhes bibliográficos
Ano de defesa: 2019
Autor(a) principal: Dayse Helena Lages da Silva
Orientador(a): Não Informado pela instituição
Banca de defesa: Não Informado pela instituição
Tipo de documento: Dissertação
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Universidade Federal de Minas Gerais
UFMG
Programa de Pós-Graduação: Não Informado pela instituição
Departamento: Não Informado pela instituição
País: Não Informado pela instituição
Palavras-chave em Português:
Link de acesso: http://hdl.handle.net/1843/SMOC-BBAHQC
Resumo: Lymphoma is the most common neoplasm in cats, presenting several anatomical forms, the most common being gastrointestinal. However, involvement of the gammaretrovirus may predispose the presentation of other anatomical forms such as the mediastinal and multicentric. The objective of this work was to conduct a retrospective study of feline lymphoma and to correlate the anatomical form, the immunophenotype with the presence of feline leukemia virus proviral DNA (FeLV), for which 56 cases were evaluated. The most common form of lymphoma was gastrointestinal. There was no significant difference in the proportion between T-cell (28) and B-cell lymphoma (26). Using DNA extracted from paraffinized tissue from 29 cats, 24 positive for FeLV proviral DNA were obtained through semi nested PCR. The multicentric anatomical form had a higher percentage (37.5%) of the presence of FeLV proviral DNA, followed by mediastinal. The immunophenotype that had the highest correlation with the presence of the virus was T-cell lymphoma (50%). Apparently in Brazil, there is a high relation between the lymphoma and the presence of the proviral DNA of FeLV