Estudo de plasticidade paralela baseado em fEPSP no Hipocampo CA1

• Ano de defesa: 2018
• Autor(a) principal: Matheus Guimaraes Hofner
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Minas Gerais; UFMG
• Palavras-chave em Português: Bioquimica e imunologia; Hipocampo; Bioquímica; Memória; Transmissão Sináptica; Plasticidade neurona; Potenciais Sinápticos
• Link de acesso: http://hdl.handle.net/1843/BUOS-B2DPCW

Hippocampus is highly correlated with memory formation and rescue. Neurophysiogy shows great evidences for the existence of a spatio-temporal segregation of microcircuits in this region a dynamism regarding its activity dictated by synaptic plasticity events. By computational neurobiology, it is possible to combine electrophysiological and anatomical partterns to behavioral studies and mathematical models that are able to elucidate new directions on the way for the knowledge of brains physiology. In our study we based on the hypothesis of microcircuits segregation on CA1 region of Hippocampus to look for differences in the susceptibility of microcircuits to potentiate in front of high frequency stimulation. We found patterns of LTP that suggest an intrinsic susceptibility of potentiation of the activated microcircuit, when we stimulate in a fixed position and register in a varied position, that is independent of basal values of fEPSP and the distance of the registration position. By three consecutive tetanic stimuli, with 15 minutes intervals, we did not find plausible patterns that fit into a homogeneous setting of neuronal populations. Future analyzes will allow the study of this phenomenon, which at first suggests a possible space-time segregation of microcircuits regarding its susceptibility of potentiation evoked by TBS in the dorsal CA1 region of Hippocampus