Análise da espessura da camada de fibras nervosas da retina e da espessura macular em crianças e adolescentes com escavação normal e grande pelo cirrus OCT

• Ano de defesa: 2013
• Autor(a) principal: Diogo Cazelli Sperandio
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Minas Gerais; UFMG
• Palavras-chave em Português: Glaucoma; Relação escavação disco; Camada de fibras nervosas da retina; Crianças; Adolescente; Tomografia de coerência óptica; Técnicas de diagnóstico oftalmológico; Mácula lútea; Nervo óptico; Doenças retinianas; Fibras nervosas/patologia; Retina; Medicina; Oftalmologia; Criança
• Link de acesso: http://hdl.handle.net/1843/BUBD-9MVJ6A

Purpose: To determine retinal nerve fiber layer (RNFL) thickness and macular thickness (MT) values in normal children using Cirrus OCT® and to compare RNFL thickness and macular thickness in children with a normal and large cup-to-disc ratio. Then, to investigate the relationship between age, race, and axial length with RNFL and MT measurements. Methods: To select eyes of children aged 717 years with a normal (0.5) or large c/d ratio (0.7). Ophthalmologic tests, ultrasound biometry, ultrasound pachymetry, retinography, RNFL measurement, and macular thickness measurement were performed. Results: The study included 64 eyes with a normal c/d ratio and 38 with a large c/d ratio. The mean age of the subjects was 12.07 ± 2.49 years for males and 11.62 ± 3.04 years for females. All optical coherence tomographic data were of high quality. The average RNFL thickness in children with normal c/d ratio was 100.34 ± 10.15 m; the average thickness was 133.86 ± 14.41 m in the inferior quadrant, 128.55 ± 17.87 m in the superior quadrant, 72.22 ± 11.42 m in the nasal quadrant, and 66.67 ± 9.42 m in the temporal quadrant. The RNFL was significantly thicker on average and in all quadrants in black compared with white children. Children with a large c/d ratio exhibited reduced thickness of both the RNFL and the four quadrants compared with those with a normal c/d ratio. RNFL thickness exhibited no tendency to increase or decrease with increasing c/d ratio up to the limit of 0.5. From 0.7 there was a significant tendency to reduced thicknesses of both the RNFL and the superior and nasal quadrants. White children with a normal c/d ratio had a significantly lower RNFL thickness than black children. However, there was no difference according to race in children with a large c/d ratio. Age and axial length showed no correlation with RNFL or macular thickness. Conclusions: Normal children aged 717 years have an average RNFL thickness similar with young adults. The RNFL was thickest in the inferior quadrant and thinnest in the temporal quadrant. The RNFL thickness decreased as c/d ratio increased above a value of 0.7. Black children with a normal c/d ratio had a greater RNFL thickness than white children. Black children with a large c/d ratio had lower mean RNFL and superior quadrant thicknesses than those with a normal c/d ratio, whereas in white children no such difference was identified. Age and axial length did not affect RNFL or macular thickness. Optical coherence tomography could be an important tool in the evaluation of children with an increased c/d ratio.