Escarro induzido em crianças e adolescentes com asma de difícil controle: taxa de sucesso, segurança e tolerabilidade
Ano de defesa: | 2011 |
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Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | |
Tipo de documento: | Dissertação |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Universidade Federal de Minas Gerais
UFMG |
Programa de Pós-Graduação: |
Não Informado pela instituição
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Departamento: |
Não Informado pela instituição
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País: |
Não Informado pela instituição
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Palavras-chave em Português: | |
Link de acesso: | http://hdl.handle.net/1843/BUOS-8R2MWC |
Resumo: | Objectives: review the relevant articles on the general technique of sputum induction, its rates, safety and tolerability in children and adolescents with different levels of asthma intensity. Data source: A review of literature over recent years was performed using Lilacs, Scielo and Medline databases. Data synthesis: In this review, results of the induced sputum samples from 778 children and adolescents with asthma were analyzed. The average success rate found was 76.7±9.9 (CI 95%,76.0-77.4%), considering different cut-off points for contamination by squamous cells. Cellular viability was reported in 517 samples and a rate of 59±14.9% (CI 95%, 55.5-58.5%) was found. There was a reduction of FEV1 values greater than 20% in 2.9% (CI 95%, 1.7-4.8%) and there was raised FEV1 in all patients after the short acting ß2-agonist was administered. Side effects were reported in 18.4% (CI 95%, 15.7-22.0%) of patients, and among the most frequent were a salty taste, chest tightness, coughing and a sore throat. Only three studies reported that age and/or the asthma intensity had an influence on securing an adequate sputum sample. The majority of the studies analyzed used a high output ultrasonic nebulizer with success rate varying from 60 to 95%. Only three of them (25%) used a low output nebulizer and their success rates were between 62.5 and 100%. Conclusions: The induction sputum technique is safe and well tolerated in patients with asthma and the success rate was around 76%. |