Estudo citológico da glândula tireoide: comparação (intra e interexaminador) dos resultados com o exame histológico das peças cirúrgicas.
Ano de defesa: | 2010 |
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Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | |
Tipo de documento: | Tese |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Universidade Federal de Minas Gerais
Brasil MEDICINA - FACULDADE DE MEDICINA Programa de Pós-Graduação em Medicina - Gastroenterologia UFMG |
Programa de Pós-Graduação: |
Não Informado pela instituição
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Departamento: |
Não Informado pela instituição
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País: |
Não Informado pela instituição
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Palavras-chave em Português: | |
Link de acesso: | http://hdl.handle.net/1843/45786 |
Resumo: | A fine needle aspiration citology (FNAC) has allowed a better selection of candidates for thyroidectomy providing a reduction in the number of operated patients and increased number of malignant tumors surgically resected. However, there is a wide variation in results, which may reflect differences in experience gained in its interpretation. It is believed that the efficiency of the method is directly related to training professional. The critical parameter of the clinical usefulness of a diagnostic test is its interobserver variability, and especially intraobserver. The objectives of this study was to evaluate the influence of the examiner's experience in the interpretation of cytological findings of thyroid and to correlate the cytologic findings issued by pathologists with and without experience, with the histological examinations of surgical specimens and to evaluate the influence of a broad definition of malignancy (BDM) instead of using the narrow definition of malignancy (NDM) on the calculations of measures and validation of diagnostic prediction. The results revealed consistent intraobserver reproducibility after the lapse of six months, both for the experienced pathologist (K = 0.82 [0.71 to 0.94], Kp = 0.79, p = 0.988) and for non-experienced (K = 0.78 [0.64 to 0.91], Kp = 0.71, p = 0.291). There was no difference for the inexperienced and experienced pathologist, respectively, in terms of rate: insufficient material (p = 0.72, p = 0.48), follicular neoplasm (FN) (p = 1.0, p = 0,09), falsepositive (p = 1.0, p = 0.72), false-negative using the NDM (p = 0.55, p = 0.60), false-negative using the BDM (p = 0.72, p = 0.72), proportion of malignant tumors identified using the NDM (p = 1.0, p = 0.59) and BDM (p = 1.0, p = 0,66). The analysis of interobserver reproducibility showed a significant difference in both the first moment (K = 0.55 [0.38 to 0.72], Kp = 0.50, p = 0.011) or the second afther six months (K = 0,54 [0.37 to 0.71], Kp = 0.44, p = 0.021). There was also a difference in the number of unsatisfactory results in both the first (p = 0.001) and second examination (p = 0.021), and FN in the second analysis (p = 0.015). However, no difference in the proportion of malignant tumors identified in the first (p = 0.79 [NDM], p = 0.81 [BDM]) and the second analysis (p = 0.78 [NDM], p = 0,50 [BDM]), as well as false-positive (p = 0.62, p = 0.21) and false-negative in the first analysis (p = 0.55 [NDM], p = 0.72 [BDM]) and the second analysis (p = 0.60 [NDM], p = 0.72 [BDM]). Conclude that the intraobserver reproducibility in the interpretation of FNA cytology is consistent and independent of experience to the survey, however, the interobserver reliability is influenced. The experience of the examiner influences significantly the proportion of unsatisfactory results and cases compatible with FN. The use of the NDM should be avoided when interpreting the case compatible with FN, in view of the high rate of malignancy observed in these samples, even when the reports are issued by experienced pathologists. Surgical indication of thyroid nodules should take into account the high rate of false-negative results observed at the FNAC, which occurs even when performed by experienced pathologist, as well as the high rate of unsatisfactory results, mainly due to the high rates of malignancy observed in these samples. |