Associação entre os polimorfismos dos genes GSTM1 e GSTT1 e a leucoplasia bucal

• Ano de defesa: 2005
• Autor(a) principal: Eliza Carla Barroso Duarte
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Minas Gerais; UFMG
• Palavras-chave em Português: GTSM1; Leucoplasia oral; Polimorfismo; Polimorfismos (Genética); Leucoplasia bucal
• Link de acesso: http://hdl.handle.net/1843/ZMRO-6UVHJA

We investigated the frequency of the GSTM1 genotypes in 104 tobacco smoking subjects in a Brazilian population. The GSTM1 genotypes were studied by PCR-based methods. The frequency of the GSTM1 null genotype in the group with oral leukoplakia (57.7%) was statistically different from the controls (34.6%) (Odds ratio, O.R.=2.57, 95% C =1.16-5.69, P0.05). The stratification of the samples according to the level of dysplasia showed increased prevalence of GSTM1 null genotype on lesions with moderate/severe histological dysplasia (68.2%) compared to the control group (31.9%). This difference was statistically significant (O.R.=4.59, 95% CI=1.29-16.33, P0.05). In conclusion, the GSTM1 null genotype may increase the risk for oral leukoplakia development.