Avaliação da presença de marcadores da resposta inflamatória e angiogênese em sangue periférico e menstrual de mulheres portadoras de endometriose

• Ano de defesa: 2013
• Autor(a) principal: Claudia Maria da Silva
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Minas Gerais; UFMG
• Palavras-chave em Português: endometriose; sangue menstrual; angiogênese; inflamação; Endometriose; Menstruação; Estudos transversais; Biomarcadores; Medicina; Inflamação
• Link de acesso: http://hdl.handle.net/1843/BUBD-AX4FT2

Inflammation and angiogenesis appear to play an important role in the pathogenesis of endometriosis. We aimed at evaluating the presence of inflammation and angiogenesis markers myeloperoxidase (MPO), N-acetyl--D-glucosaminidase (NAG), tumor necrosis factor alpha (TNF-) and vascular endothelial growth factor (VEGF) in peripheral and menstrual blood in women with and without endometriosis. This transversal study included 17 women: endometriosis (n=10) and control (n=7). Menstrual and peripheral blood samples were collect between 1st and 4th day of menses. NAG and MPO activity was evaluated by enzymatic methods, whereas TNF- and VEGF by immunoassay. When groups were compared, no statistical difference were found for NAG, MPO, TNF- and VEGF nor in the menstrual nor in peripheral blood. Menstrual blood NAG and MPO activities in the endometriosis group were significantly higher in comparison to peripheral blood, p = 0.039 and 0,0117 respectively. Both, NAG and MPO presented positive linear correlation in peripheral, (p = 0,07; r = 0,641) and menstrual blood, (p = 0,01; r = 0,603). Comparison between symptomatic patients and asymptomatic for NAG, MPO, TNF- and VEGF revealed no statistical difference. We confirmed the presence of inflammatory and angiogenesis markers in the menstrual blood. NAG and MPO activity were significantly higher in the menstrual blood of endometriosis patients and NAG and MPO presented a positive linear correlation in both, menstrual and serum blood, which could account for increased local inflammatory activity in these women.