Análise sérica de leptina, IL-6, IGF-1 e estrógeno em cadelas com excesso de peso e carcinomas mamários em estadio inicial

• Ano de defesa: 2017
• Autor(a) principal: Stefane Valgas Teixeira
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Minas Gerais; UFMG
• Palavras-chave em Português: Patologia; Neoplasias da mama; Medicina; Obesidade; Leptina/análise; Estadiamento de neoplasias; Cães
• Link de acesso: http://hdl.handle.net/1843/BUBD-AX9JMQ

Mammary gland neoplasms are the most frequent in bitches, where approximately 84% are classified as malignant, and 98% are characterized as carcinomas. Obesity is considered a chronic and multifactorial disease with an incidence between 22% and 40% in the canine species, being associated with several other diseases, among them breast cancer. The aim of this study was to relate the serum concentration IL6, IGF-1, leptin and estrogen in non-castrated bitches with or without overweight and early stage mammary carcinomas. Forty-three bitches were divided into four groups, two groups without mammary carcinomas with overweight (10/43) and without (10/43) and two groups of bitches with mammary carcinomas with (13/43) and without overweight (10/43). Overweight bitches, with or without breast carcinomas, were statistically different from bitches by ideal weight, in relation to ECC, IMCC and body fat percentages (p<0,0001). There was a positive correlation between ECC and IMCC (r = 0.8686, p <0.0001), ECC and % GC (r = 0.8808, p <0.0001), and IMCC and % GC (r = 0.7449, p <0.0001). Analyzes of estrogen, leptin, IL-6 and IGF-1 did not show statistically significant differences between the groups studied. A positive correlation was found between serum leptin and IL-6 (r = 0.3072, p = 0.0451) and leptin and IGF-1 (r = 0.2998, p = 0.05). A positive correlation (r = 0.4493; p = 0.0053) between ECC and leptin was found in the analysis of body evaluation methods and serum concentrations, and a negative correlation between ECC and IL-6 (R = -0.3591, p = 0.0435). Among the fat percentage and the leptin concentration, there was a positive correlation (r = 0.4996; p = 0.0016), as found between the IMCC and leptin (r = 0.3785; p = 0, 0209). The present study demonstrated a direct relationship between overweight and an increase in fat percentage with leptinemia. However, no differences were observed in IL-6, IGF-1 and estrogen levels in relation to overweight and mammary carcinomas. In the sample studied, no association was observed between overweight and the presence of early stage mammary carcinomas.