Ação da prednisona e prednisolona sobre o canal para potássio Kv1.3

Detalhes bibliográficos
Ano de defesa: 2022
Autor(a) principal: Pedro Henrique Cardoso de Castro
Orientador(a): Não Informado pela instituição
Banca de defesa: Não Informado pela instituição
Tipo de documento: Dissertação
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Universidade Federal de Minas Gerais
Brasil
ICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICA
Programa de Pós-Graduação em Ciências Biológicas - Farmacologia Bioquímica e Molecular
UFMG
Programa de Pós-Graduação: Não Informado pela instituição
Departamento: Não Informado pela instituição
País: Não Informado pela instituição
Palavras-chave em Português:
Link de acesso: http://hdl.handle.net/1843/57845
https://orcid.org/0000-0003-0116-3875
Resumo: Ion channels are integral proteins on cell membrane that form pores in the lipid bilayer, allowing the selective passage of ions. Ion channels play roles in multiple physiological processes, such as muscle contraction; memory and learning; release of neurotransmitters and hormones; control of cell proliferation, among others. Voltage-gated potassium channels are present in the plasma membrane of virtually every cell and are responsible for the resting potential, the repolarization phase of the action potential, and the control of cell proliferation. Voltage-gated potassium channels KV1.3 are expressed in the plasma membrane of T lymphocytes and are recognized as promising targets in the therapeutic treatment of autoimmune diseases, since these channels play pivotal role in the activation and proliferation of T lymphocytes. Autoimmune diseases are associated with an exacerbated immune reaction mediated by T lymphocytes. KV1.3 channels blockers are known as immunomodulating agents and their use as therapeutic target has shown great efficacy in the treatment of these pathologies. Among drugs that are used in the treatment of autoimmune diseases, prednisone and prednisolone, synthetic corticoids, were studied to analyze the electrophysiological changes caused by these drugs on KV1.3 channels, showing that both could promote significant, direct, and reversible blockade of the potassium currents flowing through the KV1.3 channels. There are no studies demonstrating interactions between these corticosteroids and KV1.3 channels, so investigating these interactions contributes to the outlining of the mechanisms involved in the response of these drugs in autoimmune diseases.