Determinação de rutina sobre nanotubos de carbono modificados com ciclodextrina

Detalhes bibliográficos
Ano de defesa: 2021
Autor(a) principal: SANTOS NETO, Antonio Gomes dos lattes
Orientador(a): TANAKA, Auro Atsushi lattes
Banca de defesa: TANAKA, Auro Atsushi lattes, PASSOS, Raimundo Ribeiro lattes, LIMA, Roberto Batista de
Tipo de documento: Dissertação
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Universidade Federal do Maranhão
Programa de Pós-Graduação: PROGRAMA DE PÓS-GRADUAÇÃO EM QUÍMICA/CCET
Departamento: DEPARTAMENTO DE QUÍMICA/CCET
País: Brasil
Palavras-chave em Português:
flavonóides;
rutina;
y-ciclodextrina;
nanotubos de carbono;
Palavras-chave em Inglês:
flavonoids;
rutin;
y-cyclodextrin;
carbon nanotubes.
Área do conhecimento CNPq:
Química
Link de acesso: https://tedebc.ufma.br/jspui/handle/tede/3721
Resumo: Flavonoids have gotten the interest of many research laboratories in virtue of the many health benefits these compounds provide, such as: antioxidant, anti-cancer, anti-aging properties and contribution to the formulation of drugs. Due to the environmental, biochemical, chemical and pharmacological importance, the accurate determination of flavonoids has gained significant attention in the scientific community. This work presents the development of an electrochemical platform based on multi-walled carbon nanotubes (NTCPM) modified with hydroxpropyl-y-cyclodextrin (y-CD) for the determination of rutin in nanomolar concentration levels in pharmacological and in regional plants extracts. To do so, the surface modification of NTCPM with y-CD was evaluated with Fourier-transform infrared spectroscopy (FTIR) and electrochemical impedance spectroscopy (EIS). Electrochemical measurements were performed using the NTCPM- (y-CD) system and different voltammetric techniques, which allowed to define the square wave voltammetry (VOQ) as the most appropriate and to establish, under optimized experimental conditions, the linear range between 39,22 and 975,00 nmol L-1 for the detection of rutin in aqueous solutions. Limits of detection (LOD), quantification (LOQ) and sensitivity of 24.39 nmol L -1 , 0.032 µA L nmol-1 and 7.32 nmol L -1 were found, respectively. The selectivity for possible interferents, including two flavonoids, was tested with recovery rates of pharmacological and in extracts plants samples close to 100%, besides HPLC validation.

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