Detalhes bibliográficos
| Ano de defesa: |
2024 |
| Autor(a) principal: |
Costa, Marillia Lima
 |
| Orientador(a): |
Zapata, Marco Tulio Antonio Garcia
|
| Banca de defesa: |
Zapata, Marco Tulio Antonio Garcia,
Teixeira, Antônio Raimundo Lima Cruz,
Silva, Hugo Delleon da,
Anunciação, Carlos Eduardo,
Cardoso, Clever Gomes |
| Tipo de documento: |
Tese
|
| Tipo de acesso: |
Acesso aberto |
| Idioma: |
por |
| Instituição de defesa: |
Universidade Federal de Goiás
|
| Programa de Pós-Graduação: |
Programa de Pós-graduação em Ciências da Saúde (FM)
|
| Departamento: |
Faculdade de Medicina - FM (RMG)
|
| País: |
Brasil
|
| Palavras-chave em Português: |
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| Palavras-chave em Inglês: |
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| Área do conhecimento CNPq: |
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| Link de acesso: |
http://repositorio.bc.ufg.br/tede/handle/tede/13544
|
Resumo: |
Introduction: The possibility of sexual transmission of Trypanosoma cruzi was suggested by Carlos Chagas after the discovery of the disease. However, the infectivity of semen samples and sexual transmission of the parasite on animal models occurred recently with few studies evaluating this transmission mechanism in humans. Objectives: to investigate the possibility of sexual transmission of trypanosomatids and T. cruzi, both in experimental animals and human. Methods: a scopimg review associated with an observational study was conducted. The search for studies was performed in the databases PubMed, Lilacs, Global Health and Portal CAPES with the following terms: “Trypanosomids”, “Trypanosoma”, “Leishmania”, “Sexual Transmission”, “Sêmen”, “Vaginal Secretion”, “Male”, “Female”, in English, Spanish and Portuguese. An observational study was also conducted to investigate the sexual transmission of T. cruzi in a population of 171 individuals distributed across 10 families residing in the municipality of São Felipe, Bahia. Blood and semen samples obtained were analyzed by serological and molecular methods, combined with socio-epidemiological information obtained from a questionnaire, in order to confirm or exclude the sexual transmission of T. cruzi. Results: According to the eligibility criteria 27 articles were found. Literature reports showed the presence of protozoa of Leishmania and Trypanosoma genus in reproductive organs and sexual fluids, as well as the sexual transmission of these parasites to sexual partners and offspring. In the observational study, the presence of T. cruzi in blood samples was found in 24,56% through molecular testing. Epidemiological analysis indicated that the infected group consisted predominantly of women, aged 20 to 50 years, married, self-identified as black, rural workers, born in the rural areas of the municipality, with low socioeconomic status and educational level. Analysis of semen samples revealed the protozoan in only one semen samples, with the presence confirmed by sequencing technique. The association of molecular findings from blood and semen analyses and information extracted from the applied questionnaire identified at least three cases of women who acquired the infection through sexual transmission. Conclusion: based on the information obtained from the review, as well as the presence of T. cruzi in semen samples, it was possible to conclude that trypanosomatids, especially T. cruzi, can be sexually transmitted, with semen being an infective fluid |
