INVESTIGAÇÃO DO POTENCIAL TÓXICO DO EXTRATO BRUTO ETANÓLICO DAS SEMENTES DE ANNONA CORIACEA MART. (ARATICUM) EM CAMUNDONGOS SUBCRONICAMENTE EXPOSTOS

• Ano de defesa: 2008
• Autor(a) principal: NASCIMENTO, Guilherme Nobre Lima do
• Orientador(a): BOZINIS, Marize Campos Valadares
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Goiás
• Programa de Pós-Graduação: Mestrado em Ciências Farmacêuticas
• Departamento: Ciências da Saúde - Farmácia
• País: BR
• Palavras-chave em Português: Annona coriacea Mart.; toxicologia; neurotoxicidade; hepatotoxicidade; nefrotoxicidade; 1. Araticum (Annona coriacea Mart) 2. Plantas medicinais Toxicidade Avaliação 3.Neurotoxicidade 4. Hepatotoxicidade 5. Nefrotoxicidade
• Palavras-chave em Inglês: Annona coriacea MART; toxicology; neurotoxicity; hepatotoxicity; nephrotoxicity
• Área do conhecimento CNPq: CNPQ::CIENCIAS BIOLOGICAS::FARMACOLOGIA
• Link de acesso: http://repositorio.bc.ufg.br/tede/handle/tde/2124

The araticum (Annona coriacea Mart.) is a typical fruit of the brazilian cerrado used popularly to overcome inflammatory processes. The family Annonaceae presents as the main constituents acetogenins, a class of substances with great cytotoxic and genotoxic potential, and cited as responsible for a disease similar to parkinson in a Caribbean population that used the fruit as much as food and for medicinal purposes. The aim of this study was to evaluate the putative activity of crude ethanolic extract of seeds of A. coriacea on the cerebral cortex of mice exposed at doses of 12.5, 25, 50 and 100 mg / kg, and evaluate its activity on different areas of the brain, the liver and kidneys. We used 30 adult male Swiss mice divided into groups control, solvent and treated (12.5, 25, 50 and 100 mg / kg). The extract was administered orally for four days. The target organs were extirpated, fixed in 70% ethanol (v / v) and processed for histological method - hematoxylin and eosin. The analysis of the slides was performed by image processing system for counting cells and other morphometric analysis. The morphological studies showed no significant changes to the brain in different areas, just as no changes were detected in the kidneys. On the other hand, was found a reduction on the frequency of cells per area of the liver, like as an reduction on the consumption of food, water and production of excreta. We conclude with this work a possible hepatotoxic activity induced by exposure to crude ethanol extract of seeds of A. Coriacea Mart., observed by the decrease in frequency of cells per area of the liver, correlated with reductions in consumption of food / water and production of excreta by animals.