Frequência das lesões cutâneas no lúpus eritematoso sistêmico

• Ano de defesa: 2017
• Autor(a) principal: Rocha, Ana Carolina Naves de Castro
• Orientador(a): Silva, Nilzio Antônio da
• Banca de defesa: Silva, Nilzio Antônio da, Barbosa, Vitalina de Souza, Fernandes, Marcos Rassi, Oliveira, Cacilda Pedrosa de
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Goiás
• Programa de Pós-Graduação: Programa de Pós-graduação em Ciências da Saúde (FM)
• Departamento: Faculdade de Medicina - FM (RG)
• País: Brasil
• Palavras-chave em Português: Lúpus eritematoso sistêmico; frequência das lesões cutâneas no LES; Fenotipo das lesões cutâneas no LES; manifestações cutâneas no LES
• Palavras-chave em Inglês: Systemic lúpus erythematosus; Cutaneous lesions frequency; Phenotype of cutaneous lesions in SLE; Cutaneous manifestations in SLE
• Área do conhecimento CNPq: CIENCIAS DA SAUDE::MEDICINA
• Link de acesso: http://repositorio.bc.ufg.br/tede/handle/tede/8015

Systemic lupus erythematosus (SLE) is an autoimmune, systemic, chronic inflammatory disease. The ACR (American College of Rheumatology) considers 4 skin findings as attributes for classifying SLE, while the Systemic Lupus International Collaborating Clinics (SLICC) has added new cutaneous lesions as classification criteria. The purpose of the present study is to quantify cutaneous lesions in SLE and associate them with other disease elements (demographics, ANA antibodies, extracutaneous lesions and disease activity) in patients treated at a renowned reference hospital in Brazil’s center-west region. Methods: Patients diagnosed with SLE in the HC/FMUFG unit were selected, and 97 of them were enrolled. A clinical consultation, along with medical records, provided collected data. SLEDAI score was used for measuring disease activity. The skin findings were categorized in groups according to the SLICC´s critera. Association and descriptive analysis of the qualitative variables were used, using absolute (n) and relative (%) frequencies. Results: Subjects were 86 females and 11 males of mixed ethnicities. Among LE specific lesions, malar rash was predominant, accounting for 33 patients (32.98%). Photosensitivity was found in 30.92% of patients, equivalent of Subacute Cutaneous Lupus Erythematosus (SCLE), discoid lesions in 9.27%, whilst lupus panniculitis comprised 3.9%. Hypertrophic and chilblain lupus represented both 2.06%. We found 72.16% patients with active disease and 81.4% with positive ANA. Conclusions: At least one skin lesion was present in 60,8% of the patients. In this Brazilian population, malar rash remains the main presentation of skin lesions in SLE, followed by SCLE and photosensitivity. We found no important association among skin lesions and SLEDAI score, ethnicity, age or gender. ANA antibodies was associated with alopecia (both cicatricial and non-cicatricial). Further studies are necessary in order to establish precise disease activity correlation and guided prognosis through skin findings. A deeper understanding of cutaneous lesions in SLE may provide a better disease management.