AVALIAÇÃO DA TOXICIDADE ORAL AGUDA E DAS ATIVIDADES DIURÉTICA E ANTIOXIDANTE, DA Rudgea viburnoides (CHAM.) BENTH. (CONGONHA-DE-BUGRE)

• Ano de defesa: 2009
• Autor(a) principal: PUCCI, Liuba Laxor
• Orientador(a): CUNHA, Luiz Carlos da
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Goiás
• Programa de Pós-Graduação: Mestrado em Ciências Farmacêuticas
• Departamento: Ciências da Saúde - Farmácia
• País: BR
• Palavras-chave em Português: Plantas medicinais; Rudgea viburnoides; Atividade diurética. Atividade antioxidante; Toxicidade aguda
• Palavras-chave em Inglês: Medicinal plants; Rudgea viburnoides; Diuretic activity; Antioxidant activity; Acute toxicity
• Área do conhecimento CNPq: CNPQ::CIENCIAS DA SAUDE::FARMACIA
• Link de acesso: http://repositorio.bc.ufg.br/tede/handle/tde/2126

The Rudgea viburnoides (Cham.) Benth. (Rubiaceae), popularly known as "congonha, congonha-de-Bugre or Bugre" is used in folk medicine as diuretic, hypotensive, anti-rheumatic and depurative of blood (leaves tea). This species is being traded as "porangaba" and used in weight loss programs. This work aimed to study the acute toxicity, the diuretic and antioxidant activities of R. viburnoides. The test for acute toxicity in single dose was performed with the ethanolic crude extract, administered orally, at concentrations of 2000mg/kg and 5000mg/kg in mice and rats of both sexes by the testo of Class.To test for diuretic activity in rats, it was used the crude ethanolic extract of the leaves at concentrations of 40mg/kg, 80mg/kg and 160mg/kg, and furosemide 20mg/kg as positive control. The determination of total phenols of the crude extract and fractions (hexane, dichloromethane, ethyl acetate and methanol/water) was performed by the method of Butler and Hargerman and the evaluation of antioxidant activity performed by the method of 2,2-diphenyl-1- picryl -hidrazil (DPPH). There was no acute toxicity of crude ethanolic extract of the leaves and it was classified as non toxic.The results has shown that the ethanolic extract presented dependent dose diuretic effect higher than furosemide, used as positive control. The crude ethanolic extract showed 0.84% of total phenols, the fraction hexanic 0.44%, the dichloromethane fraction 1.91%, the fraction of ethyl acetate fraction 15.43% and the fraction methanol/water 7.92%. The ethyl acetate fraction showed better antioxidant action. The results obtained so far may justify the popular use of Rudgea viburnoides as diuretic