Soroprevalência da infecção pelo vírus da hepatite E em pacientes transplantados renais em Goiânia - Goiás

• Ano de defesa: 2016
• Autor(a) principal: Oliveira, Jerusa Marielle Nunes Seabra de
• Orientador(a): Martins, Regina Maria Bringel
• Banca de defesa: Turchi , Marília Dalva, Aires , Rodrigo Sebba, Martins , Regina Maria Bringel
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Goiás
• Programa de Pós-Graduação: Programa de Pós-graduação em Medicina Tropical e Saúde Publica (IPTSP)
• Departamento: Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG)
• País: Brasil
• Palavras-chave em Português: Hepatite E; Transplante renal; Hepatitis E; Kidney transplantation
• Área do conhecimento CNPq: CLINICA MEDICA::DOENCAS INFECCIOSAS E PARASITARIAS
• Link de acesso: http://repositorio.bc.ufg.br/tede/handle/tede/8802

Hepatitis E virus (HEV) infection is an important cause of acute hepatitis in the world; in addition it may cause chronic infection and rapid progression to cirrhosis in renal transplant recipients. Despite of the relevance of this subject, the investigations concerning HEV in Brazil are still rare. This is the first study in the Midwest region aiming to estimate the seroprevalence of hepatitis E virus infection in renal transplant patients in Goiânia, Goiás. Cross-sectional study in renal transplant patients who were seen at Santa Casa de Misericordia de Goiânia from April to November 2014. Among 370 patients who were registered, 316 were interviewed and blood was collected to obtain serum samples. Of these, 10 samples were anti-HEV IgG reactive and one indeterminated by enzyme linked-immunosorbent assay (ELISA). Eight samples were subsequently confirmed as positive using immunoblot, resulting in a prevalence of 2.5% (95% CI 1.2-5.1). The anti-HEV IgM marker was detected in only one sample by ELISA/immunoblot. HEV RNA was not detected in the anti-HEV-positive samples. The studied population and patients exposed to HEV showed risk behaviors/practices related to parenteral, fecal-oral, and zoonotic transmission. The findings of this study show a low seroprevalence of HEV infection, indicating a reduced circulation of HEV in renal transplant pacients in Goiânia, Goiás.