Soroprevalência e genótipos dos vírus das hepatites C e G em pacientes renais crônicos em um centro de diálise em Goiânia-GO

• Ano de defesa: 2002
• Autor(a) principal: Ramos Filho, Ramon
• Orientador(a): Regina Maria Bringel Martins, Regina Maria Bringel Martins
• Banca de defesa: Lampe, Elisabeth, Daher, Roberto Ruhman, Martins, Regina Maia Bringel
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Goiás
• Programa de Pós-Graduação: Programa de Pós-graduação em Medicina Tropical e Saúde Publica (IPTSP)
• Departamento: Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG)
• País: Brasil
• Palavras-chave em Português: Genótipos dos vírus das hepatites C e G; Renais crônicos
• Palavras-chave em Inglês: Hepatitis C and G; State renal disease
• Área do conhecimento CNPq: CLINICA MEDICA::DOENCAS INFECCIOSAS E PARASITARIAS
• Link de acesso: http://repositorio.bc.ufg.br/tede/handle/tede/6163

Patients with renal failure are at high risk of acquiring viral hepatitis thought blood transfusion, kidney transplant and nosocomial transmission. High prevalence of hepatitis C (HCV) and G (HGV) have been observed among these patients. To assess the prevalence of infection by these viruses in a dialysis unit, 123 patients in Goiânia- Goias were interviewed and blood colleted. They were tested for the presence of antibodies to HCV (anti-HCV) and RNA-HCV, and to detect RNA-HGV. RNA viral positive samples were genotyped. An overall prevalence of 37.4% and 14.6% for hepatitis C and G viruses were found respectively. Patients in hemodyalisis (41.8% and 15.3%) and renal transplanted subjects (33.3% and 16.7%), had higher rates of positivity for the virus C and G when compared to patients in peritoneal dialysis (7.7%). Genotype 1 (54.8%) and 3 (45.2%) of HCV were the most frequently found, and the subtypes 1a and 3a were prevalent. Regarding HGV genotypes 1 (17%), 2 (72%) and 3 (11%) were found, with predominance of subtype 2b. A co-infection by C and G viruses of 3.2% was observed. History of blood transfusions, the duration of end-stage renal disease and co-infection with hepatitis B were risk factors associated with infection by virus C. The patients infected with HGV reported blood transfusion, treatment with a non graduated dentist and sexually transmitted disease as risk factors, beside most of them had been in hemodyalisis. Our data showed a high prevalence for HCV infection in this population, in spite of the screening for blood products and the adoption of universal precautions in dialysis units, and also a high prevalence of HGV in this population was observed.