Detalhes bibliográficos
| Ano de defesa: |
2019 |
| Autor(a) principal: |
Gonçalves, Marcilia Viana Pavam
 |
| Orientador(a): |
Lima, Eliana Martins
|
| Banca de defesa: |
Lima, Eliana Martins,
Silva, Lorena Maione,
Nascimento, Thais Leite,
Souza, Ana Luiza Ribeiro de |
| Tipo de documento: |
Dissertação
|
| Tipo de acesso: |
Acesso aberto |
| Idioma: |
por |
| Instituição de defesa: |
Universidade Federal de Goiás
|
| Programa de Pós-Graduação: |
Programa de Pós-graduação em Ciências Farmacêuticas (FF)
|
| Departamento: |
Faculdade Farmácia - FF (RG)
|
| País: |
Brasil
|
| Palavras-chave em Português: |
|
| Área do conhecimento CNPq: |
|
| Link de acesso: |
http://repositorio.bc.ufg.br/tede/handle/tede/10225
|
Resumo: |
A lot of progress has been made in the past decades in the development of nanoparticles as carriers of antitumor drugs, and today, with the successes achieved with cancer immunotherapy, many advances have been made with the use of nanoparticles to arouse effective immune response against tumor cells. In this study, hybrid synthetic phospholipids associated to phospholipids and cell membrane proteins from B16F10 cells were developed. Through the microfluidization technique hybrid liposomes of 130 µm average diameter were obtained. Thus, by studying the membrane fluidity and mobility, the interaction between the phospholipids could be confirmed by the Electron Paramagnetic Resonance (EPR) technique. Finally, a model of murine cutaneous melanoma was standardized from the inoculation of cells of tumor line B16F10, the same ones used to obtain hybrid liposomes, in order to pave the way for future studies on the in vivo immune response. |
