Fatores prognósticos relacionados à mortalidade em pacientes com esclerose lateral miaotrófica em ventilação não invasiva

• Ano de defesa: 2018
• Autor(a) principal: Matos, Lorine Uchôa Inácio
• Orientador(a): Rabahi, Marcelo Fouad
• Banca de defesa: Rabahi, Marcelo Fouad, Silva, Daniela Graner Schuartz Tannus, Moreira, Maria Auxiliadora Carmo, Costa, Lusmaia Damaceno Camargo
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Goiás
• Programa de Pós-Graduação: Programa de Pós-graduação em Ciências da Saúde (FM)
• Departamento: Faculdade de Medicina - FM (RG)
• País: Brasil
• Palavras-chave em Português: ELA; Ventilação não invasiva; Traqueostomi; Mortalidade.
• Palavras-chave em Inglês: ALS; Non-invasive ventilation; Tracheostomy; Mortality
• Área do conhecimento CNPq: CIENCIAS DA SAUDE
• Link de acesso: http://repositorio.bc.ufg.br/tede/handle/tede/11109

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease without curative treatment to date. Respiratory failure is the leading cause of mortality in the disease and noninvasive home ventilation is the most effective treatment. The objective of this study was to investigate prognostic factors related to death in patients with amyotrophic lateral sclerosis using noninvasive home ventilation. A retrospective cohort study was carried out in individuals with ALS in the home NIV, admitted to a specialized center for the treatment of neuromuscular diseases in Goiânia, Goiás. The medical records of 144 patients were evaluated through a standardized data collection form. The prevalence of death in the studied population was 56.9%, being associated with age ≥ 60 years (Odds Ratio adjusted 2.76, 95% CI 1.37-5.58, p <0.001), inability to perform spirometry (Adjusted odds ratio 2.34, 95% CI 1.17- 4.70, p = 0.02) and diurnal hypercapnia (unadjusted Odds Ratio 10.78, 95% CI 1.26-92.35, p = 0.03) . The time between the onset of symptoms and the institution of NIV proved to be a significant factor for the occurrence of death (p <0,007). These findings suggest that the earlier diagnosis of amyotrophic lateral sclerosis, reduces the mortality in this disease.