Detalhes bibliográficos
| Ano de defesa: |
2015 |
| Autor(a) principal: |
Marques, Juliana Menara de Souza
 |
| Orientador(a): |
Matos, Márcia Alves Dias de
|
| Banca de defesa: |
Matos, Márcia Alves Dias de
,
Carneiro, Megmar Aparecida dos Santos,
Martins, Regina Maria Bringel |
| Tipo de documento: |
Dissertação
|
| Tipo de acesso: |
Acesso aberto |
| Idioma: |
por |
| Instituição de defesa: |
Universidade Federal de Goiás
|
| Programa de Pós-Graduação: |
Programa de Pós-graduação em Biologia das Interações Parasito-Hospedeiro (IPTSP)
|
| Departamento: |
Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG)
|
| País: |
Brasil
|
| Palavras-chave em Português: |
|
| Palavras-chave em Inglês: |
|
| Área do conhecimento CNPq: |
|
| Link de acesso: |
http://repositorio.bc.ufg.br/tede/handle/tede/6493
|
Resumo: |
Hepatitis B and diabetes mellitus (DM) represent major public health issues. Research has reported that diabetic patients are at increased risk for acquiring HBV, development of chronic liver disease, cirrhosis and liver cancer. Nevertheless, there is no data published related to this theme in Brazil. Thus, this is the first investigation in our country with this population. The aim of this study was to investigate the seroepidemiological profile of HBV infection in patients with type 2 diabetes mellitus in Goiânia, Goiás. Diabetic patients from five public health units in Goiânia city were invited to participate in the study. Thus, 605 patients were interviewed about sociodemographic characteristics, vaccination against hepatitis B and factors associated with HBV infection and the blood was collected, processed and stored (serum) to -20°C in the Laboratory of Virology (IPTSP / UFG). All serum samples were screened for the detection of HBsAg, anti-HBc and anti-HBs by enzyme-linked immunosorbent assay (ELISA). Data were analyzed using the statistical program STATA (13.1). The prevalence rates were calculated with 95% confidence interval and was estimated the prevalence ratio (PR) of individuals exposed to HBV (antiHBc positive) associated with the factors investigated. Logistic regression was performed using the Poisson model. The anti-HBc alone was detected in 3.47% (95% CI: 2.21- 5.34) of the subjects and, when combined with anti-HBs, the rate was 14.38% (95% CI: 11.73 to 17.48), resulting in an overall prevalence of HBV infection of 17.85% (95% CI 14.92 to 21.19). Moreover, a low vaccination coverage (10.41%; 95% CI: 8.15 to 13.19) and a high susceptibility rate to HBV infection was observed (71.73%; 95% CI 67.93 to 75.25). A multivariate analysis of risk factors showed that age >60 years, sharing of insulin vial, use of alcohol, paid sex and multiple sexual partners were associated with HBV infection. These findings are important to the context of health surveillance and may be used to support HBV prevention, control and clinical management, which will reflect in better quality of life and health care of the diabetic population. |
