Estudo de farmacocinética comparativa entre o resveratrol e o seu complexo hidroxi-γ-ciclodextrina

• Ano de defesa: 2019
• Autor(a) principal: Diniz, Juliana Araújo
• Orientador(a): Cunha, Luiz Carlos da
• Banca de defesa: Cunha, Luiz Carlos da, Menegatti, Ricardo, Effting, Cristiane, Oluwagbamigbe, James
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Goiás
• Programa de Pós-Graduação: Programa de Pós-graduação em Ciências Farmacêuticas (FF)
• Departamento: Faculdade Farmácia - FF (RG)
• País: Brasil
• Palavras-chave em Português: Resveratrol; Biodisponibilidade; Hidroxi-γ-ciclodextrina
• Palavras-chave em Inglês: Bioavailability; Hydroxy-γ-cyclodextrin
• Área do conhecimento CNPq: FARMACOLOGIA::TOXICOLOGIA
• Link de acesso: http://repositorio.bc.ufg.br/tede/handle/tede/9978

Resveratrol is a polyphenol that induces vasodilation, antineoplastic, anti-inflammatory, antioxidant and antiplatelet activities. Despite these beneficial effects, resveratrol is characterized by limited therapeutic performance due to its low oxidation stability and low aqueous solubility. Hence, an improvement in bioavailability may be an interesting outlet for such limitations. In order to increase oral bioavailability, resveratrol was incorporated into hydroxy-γ-cyclodextrin, resulting in resveratrol-hydroxy-γ-cyclodextrin complex (RES-γ-CD). In order to verify the efficiency of the complexation, resveratrol (resveratrol + DMSO) was compared to its complex (RES-γ-CD), determining the pharmacokinetic parameters (Tmax, Cmax, AUCT, t1/2, Vd e CLT), by the oral and intravenous routes, with absolute values (F%) and relative bioavailability (FR%) being obtained. The HPLC-PDA analytical technique was validated and the pharmacokinetic parameters were statistically the same, except for a much higher Cmax of RES-γ-CD. The F% and FR% values ​​of resveratrol were higher for RES-γ-CD formulation, demonstrating better absolute and relative bioavailability than the administered resveratrol dissolved in DMSO. In conclusion, the incorporation of resveratrol into hydroxy-γ-cyclodextrin is promising to increase the bioavailability of resveratrol, which may improve its efficacy.