Terapia celular na pseudo-artrose

Detalhes bibliográficos
Ano de defesa: 2010
Autor(a) principal: Bastos Filho, Ricardo Pinheiro dos Santos
Orientador(a): Não Informado pela instituição
Banca de defesa: Não Informado pela instituição
Tipo de documento: Dissertação
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Programa de Pós-graduação em Ciências Médicas
Ciências Médicas
Programa de Pós-Graduação: Não Informado pela instituição
Departamento: Não Informado pela instituição
País: Não Informado pela instituição
Palavras-chave em Português:
Link de acesso: https://app.uff.br/riuff/handle/1/19052
Resumo: This study was done to assess the safety and efficiency of cell therapy for pseudoarthrosis. Implant of the bone marrow aspirate was compared to mononuclear cells purified extemnporaneously using the Sepax® equipment. Seven patients with nonunion of the tibia or femur were treated. Five received a percutaneous infusion of autologous bone marrow aspirated from the iliac crest, and two received autologous bone marrow mononuclear cells separated from the aspirate by Sepax®. The primary fixation method was unchanged, and the nonunion focus was not exposed. Physical examination and radiographies were done 2, 4 and 6 months after the treatment by the same physician. After the consolidation of the fracture the satisfaction of the patients was estimated using a 0 to 10 scale. No complications occurred as a result of the referred procedures. Bone consolidation was obtained in all cases within 3 to 24 weeks. The degree of patient satisfaction before and after bone consolidation was assessed, with the average value increasing from two to nine (p=0.0156). The proposed method is effective and safe for the treatment of nonunion of long bones regardless the stabilization method used.