Desmineralização em osso trabecular e osso cortical de cães submetidos à terapia com prednisona

• Ano de defesa: 2011
• Autor(a) principal: Costa, Lorena Adão Vescovi Séllos
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal do Espírito Santo; BR; Mestrado em Ciências Veterinárias; Centro de Ciências Agrárias e Engenharias; UFES; Programa de Pós-Graduação em Ciências Veterinárias
• Palavras-chave em Português: Bone densitometry; Quantitative computed tomography; Glucocorticoid induced osteoporosis; Canine; Densitometria óssea; Tomografia computadorizada quantitativa; Cão - Doenças; Osteoporose; Glicocorticóides; Tomografia; Medicina Veterinária; 619
• Link de acesso: http://repositorio.ufes.br/handle/10/5091

Glucocorticoids are drugs widely used in veterinary medicine, however, their use can trigger a series of adverse effects. The clinical trial was aimed at evaluating possible changes in bone mineral density after therapy with prednisone, using helical computed tomography. In the study, eight healthy mongrel young adult dogs were used, 4 males and 4 females. Prednisone was administered orally to animals at a daily dose of 2mg kg-1 body weight for 30 days. Bone mineral density was determined from the radiodensity values obtained from the region of cortical and trabecular bone of the vertebral body of the second lumbar vertebra, immediately before and after the period of drug administration. The experimental protocol allowed the characterization of significant (P <0.05) decreased radiodensity of trabecular and cortical bone of vertebral body of the second lumbar vertebra, but no significant demineralization was found in the cortical region. None of the dogs of the experimental group showed pathological fracture at the end of drug administration. The study showed changes in bone metabolism in dogs subjected to therapy with prednisone at a dose of 2mg kg-1 only occur early in trabecular bone, making it a recommended monitoring patients for prevention of pathological fractures.