Comparação Clínicopatológica e da Expressão da Citoqueratina-10 Entre Liquen Plano e Lesão Liquenoide Oral

• Ano de defesa: 2024
• Autor(a) principal: Moreira, Milena Duarte
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal do Espírito Santo; BR; Mestrado em Ciências Odontológicas; Centro de Ciências da Saúde; UFES; Programa de Pós Graduação em Ciências Odontológicas
• Palavras-chave em Português: Liquen plano bucal; Citoceratinas; Imuno-Histoquímica; subject.br-rjbn; Área(s) do conhecimento do documento (Tabela CNPq)
• Link de acesso: http://repositorio.ufes.br/handle/10/17317

Background: Oral lichen planus malignant transformation potential has been largely debated. Cytokeratin-10 is suggested as an indicator of a dysplastic epithelium and can be used to assess malignant progression in oral potentially malignant disorders. This study aimed to compare clinical, histopathological features and immunostaining for cytokeratin-10 between oral lichen planus and oral lichenoid lesion. Methods: Retrospective longitudinal study comparing lichen planus and oral lichenoid lesions diagnosed at the Oral Pathological Anatomy Service, analysing socio-demographic, clinicopathological data and CK-10 expression. Chi-Square, Fisher's exact test and Mann-Whitney or Student's ttests were used, when appropriate; and p-values <.05 were considered significant. Results: A total of 23 lichen planus and 23 lichenoid lesions were included. There was an association between oral lichen planus and symptomatology (p=0.031). The buccal mucosa was the most affected site in both groups, 20 cases (87.0%) in lichen planus, and 16 cases (69.6%) in oral lichenoid lesion. Bilateral (p<0.001) striae (p=0.004) are more characteristic of oral lichen planus. There was an association of oral lichen planus with degeneration of the basal layer (p=0.049), as well as with mild epithelial dysplasia (p<0.001). Cytokeratin-10 immunostaining was similar between groups. Conclusion: A continuous follow-up is necessary to identify different patterns of malignant transformation between groups of lesions, as well as a comparison with lesions with a higher malignant transformation rate.