Avaliação de mastócitos em reação liquenoide ao amálgama e líquen plano oral

• Ano de defesa: 2018
• Autor(a) principal: Mariana Saturnino de Noronha
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Minas Gerais; UFMG
• Palavras-chave em Português: Líquen plano oral; Mastócitos; Reação liquenoide; Amálgamas dentários; Erupções liquenóides; Mucosa bucal; Líquen plano bucal
• Link de acesso: http://hdl.handle.net/1843/ODON-BA3JKY

Evaluation of mast cells in amalgam lichenoid reaction and in oral lichen planus Mast cells are originate in the bone marrow and are present in inflammatory lesions such as oral lichen planus (OLP) and amalgam lichenoid reaction (ALR). These lesions are immunologically mediated and have similar clinical and histological characteristics. The aim of this study is to evaluate and compare the density and degranulation of mast cells in OLP and ALR sample. The study was approved by the Research Ethics Committee of UFMG. Thirteen OLP and ALR sample, diagnosed clinically and histologically, were obtained from the archive of the Oral and Maxillofacial Pathology Service of the Dental School of UFMG. Six fragments of normal buccal mucosa were used as control. The histological sections were submitted to toluidine blue reactions and immunohistochemistry for anti-c-kit and anti-tryptase. The results showed a higher density of mast cells marked by anti-c-kit, anti-tryptase and toluidine blue in the lesions compared to healthy mucosa (p <0.05). An increase in the density of mononuclear inflammatory cells in the A region of the ALR in relation to OLP (p <0.05) was also observed. It is concluded that mast cells are important cells in the etiopathogenesis of lesions, but the quantitative evaluation of these cells is not a consistent parameter to differentiate the lesions. Key-words: Mast cells. Lichen planus, Oral. Lichenoid reaction.