Caracterização fitoquímica e das atividades biológicas dos frutos de doze genótipos de Musa sp.

• Ano de defesa: 2023
• Autor(a) principal: Gervásio, Suiany Vitorino
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal do Espírito Santo; BR; Doutorado em Biologia Vegetal; Centro de Ciências Humanas e Naturais; UFES; Programa de Pós-Graduação em Biologia Vegetal
• Palavras-chave em Português: Atividade antiproliferativa; Câncer de Mama (MCF-7); Antioxidante; Espectroscopia do Infravermelho; Espectrometria de Massas; Agronomia
• Link de acesso: http://repositorio.ufes.br/handle/10/12711

The genus Musa, widely consumed worldwide and a crucial source of income for many countries, is gaining increasing prominence due to the recognition of its biological activities and potential applications as a functional food and raw material in the pharmaceutical industry. This study involved the chemical characterization and description of biological activities of the genotypes Vitória’, ‘Ouro da Mata’, ‘Engana Menino’, ‘Pacovan’, ‘Fhia Monalisa’, ‘Prata Catarina’, ‘Prata Zulu’, ‘Figo Verde’, ‘Nanica Alfredo Chaves’, ‘Maranhão’, ‘Tropical’ e ‘Yangambi’. Hydroalcoholic extracts of the peels and pulps of these fruits were produced by maceration and were evaluated for their levels of flavonoids, tannins, and phenols, as well as antioxidant activity using methods such as ABTS, DPPH, FRAP, and Fe2+ chelating. Additionally, antiproliferative activity was examined in breast cancer cells (MCF-7 lineage) under different exposure periods and in combination with cisplatin. The results highlight the significant influence of tannins on the evaluated biological activities, with notable antioxidant activity in the Fe2+ chelating method. Furthermore, mass spectrometry identified the presence of various molecules, such as palmitic acid, linoleic acid, linolenic acid, stearic acid, quinic acid, citric acid, and others. Regarding antiproliferative activity, the results were promising, and the exposure period played a crucial role in this action, with a high capacity to eliminate cancer cells after 72 hours for the peels and pulps extracts of all genotypes. As for the combination of extracts with cisplatin, the results also showed promise for some genotypes, especially when administered simultaneously. However, for other genotypes, the action of the extract and cisplatin was antagonistic, requiring further in-depth studies. In summary, this study highlights the potential of these banana genotypes as beneficial foods for health and as adjuvants in cancer treatment, emphasizing the importance of phenolic compounds in these functional foods.