Efeito da jabuticaba (Myrciaria caulifora), do fruto da palmeira juçara (Euterpe edulis Martius) e do jambolão (Syzugium cumini) sobre o perfil lipídico, a glicemia e a endotoxemia em camundongos submetidos à dieta de cafeteria

Detalhes bibliográficos
Ano de defesa: 2015
Autor(a) principal: Constancio, Vanessa da Silva
Orientador(a): Não Informado pela instituição
Banca de defesa: Não Informado pela instituição
Tipo de documento: Dissertação
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Universidade Federal do Espírito Santo
BR
Mestrado em Ciência e Tecnologia de Alimentos
Centro de Ciências Agrárias e Engenharias
UFES
Programa de Pós-Graduação em Ciência e Tecnologia de Alimentos
Programa de Pós-Graduação: Não Informado pela instituição
Departamento: Não Informado pela instituição
País: Não Informado pela instituição
Palavras-chave em Português:
664
Link de acesso: http://repositorio.ufes.br/handle/10/1365
Resumo: The excess body fat leads to an inflammatory reaction associated with metabolic endotoxemia and increased insulin resistance, as well as altering the lipid profile which results in damages to liver and renal function. Studies suggest that intake of antioxidant foods, such as polyphenols, provide beneficial effects on glucose and lipid metabolism. The objective of this study was to investigate the jabuticaba bark effect (Myrciaria cauliflora), pulp of açai juçara (Euterpe edulis Martius) and jambolan (Syzygium cumini) on the lipid profile, blood glucose and endotoxemia in Swiss mice underwent diet cafeteria. Initially, the fruits were freeze-dried and evaluated for their chemical composition. The biological assay included 50 adult male mice of the Swiss race divided into 5 groups (n = 10 / group), namely: the group treated with standard commercial diet (negative control), group treated with cafeteria diet (positive control) and groups test for 14 weeks who received the cafeteria diet supplemented with 2% jabuticaba bark, or pulp jambolan or pulp açai juçara lyophilized. In the 13th and 14th week were determined tolerance to insulin and glucose of animals. At the end of the experiment, we assessed weight gain, blood biochemistry, histopathology and endotoxemia. The biochemical parameters were: total cholesterol (TC) and HDL-C fractions, LDL-C, triglycerides (TAG) and C-reactive protein (CRP), aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Histopathology studies the effects of calorie diet over the area of adipocytes, fatty liver and kidney function from the number and area of the glomeruli. The endotoxemia was assessed by the concentration of lipopolysaccharide (LPS) in serum of the animals. We used the t test for comparison of results between the control group and ANOVA, and Tukey's test (a = 5%), to compare the groups supplemented with fruit and the positive control. Supplementation with 2% jambolan the cafeteria diet resulted in a significant reduction (p <0.05) CT content, LDL-C, TAG, the TC / HDL and decreased adipocyte animal area treated with the fruits. The supplementation of açai juçara was also able to reduce the content of TC, IGT, and adipocytes area, in addition to increasing glucose tolerance. On the other hand, the blemish was not effective in improving the lipid parameters related to metabolism, glucose metabolism and histopathological aspects. Supplementation with 2% lyophilized fruits did not cause positive effects in reducing weight gain, insulin resistance and endotoxemia caused by ingestion of a cafeteria diet. Furthermore, the fruits were not effective in preserving renal histology and fatty infiltration of the liver. It follows that the inclusion of jambolan and açai juçara in the diet can have positive effects on the damage caused by high fat diets, especially with regard to dyslipidemia, glucose tolerance and adipocyte hypertrophy.