Caracterização da população do Estado do Espírito Santo para análises forenses de Y-STRs

• Ano de defesa: 2019
• Autor(a) principal: Stange, Victor Santos
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal do Espírito Santo; BR; Doutorado em Biotecnologia; Centro de Ciências da Saúde; UFES; Programa de Pós-Graduação em Biotecnologia
• Palavras-chave em Português: Y-STR haplotypes; Pomeranians; Genetic distances; Ancestry; Haplótipos Y-STR; Estado do Espirito Santo; Pomeranos; Distâncias genéticas; Ancestralidade; Biotecnologia; 61
• Link de acesso: http://repositorio.ufes.br/handle/10/10968

The Espirito Santo state has been characterized by several migration events since 1535, which directly affected the demography of its population. The lack of data and a limited disclosure of haplotypes to characterize the current population of Espirito Santo, especially when related to Y-STRs, motivated this study. Through the genetic identification of samples 5 times larger than the one publicly available for studies about forensic kinship and criminal investigation, the Yfiler Plus® kit 27 Y-STR loci were used to make inferences in 409 samples collected in the State, divided into four macro regions. Population statistical tests (FST, RST and Molecular Variation Analysis - AMOVA) were performed to measure genetic distances among individuals and possible subpopulations. Although the general ES population did not present significant genetic differences among four macroregions, or when compared to other Brazilian populations, a subpopulation of Pomerania descendants was found to have a significantly distinct genetic profile from the neighboring subpopulations and even of the non-Pomeranian subpopulation of ES (variation of 2.32% in AMOVA). Genetic distances analysis showed a high proximity of the Pomeranian subpopulation with Europeans (Germans and Polish) and a high proximity of the general ES population with other Brazilian populations. The Pomeranian population is genetically much closer to Europeans from Germany and more similar to the Polish population than the German population itself, demonstrating an immigrant’s influence in the composition of the population of Espirito Santo. Therefore, we suggested the creation of a specific database for the Pomeranian community or the use of statistical correction factors for this subpopulation in forensics analysis.