Estudo de biomarcadores relacionados à agressividade e invasividade em carcinoma de células escamosas oral
Ano de defesa: | 2015 |
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Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | |
Tipo de documento: | Dissertação |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Universidade Federal do Espírito Santo
BR Mestrado em Clinica Odontológica Centro de Ciências da Saúde UFES Programa de Pós-Graduação em Clínica Odontológica |
Programa de Pós-Graduação: |
Não Informado pela instituição
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Departamento: |
Não Informado pela instituição
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País: |
Não Informado pela instituição
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Palavras-chave em Português: | |
Link de acesso: | http://repositorio.ufes.br/handle/10/8197 |
Resumo: | In tumorigenesis process, laminin-332 performs multiple biologic effects by γ2 chain, and MMP-9 acts disrupting extracellular components. We aimed to assess the molecular profile of γ2 chain and MMP-9 in leukoplakias oral high-risk, carcinoma in situ (CIS) and oral invasive carcinoma cell squamous (OSCC) and establish possible associations with clinicopathologic features. γ2 chain and MMP-9 expression were assessed by immunohistochemistry in 10 patients with high-risk malignancy lesions and 26 cases of invasive OSCC. The immunostaining of γ2 chain in high-risk lesions showed most cases with a continuous basement membrane, on the other hand the majority of invasive OSCC had a discontinuous membrane or absence. OSCC stromal cells showed a higher presence of MMP-9 compared to cases of high-risk lesions. The association between clinical and expression profile demonstrated that smokers with invasive OSCC had a higher expression of γ2 chain in epithelium and MMP-9 in invasive fronts. A higher expression of MMP-9 in stromal cells was associated with male patients, older than 60 years and diagnosed with invasive OSCC when compared with high-risk lesions. Our results indicate an association between clinical and microscopic features in oral lesions with high malignant potential and oral carcinomas, with a progressive change in γ2 chain and MMP-9 expression during tumorigenesis. |