Potencial fotoprotetor e genoprotetor da própolis vermelha produzida por apis mellifera no semiárido do rio grande do norte, brasil

Detalhes bibliográficos
Ano de defesa: 2019
Autor(a) principal: Menezes, Manuela Costa de
Orientador(a): Não Informado pela instituição
Banca de defesa: Não Informado pela instituição
Tipo de documento: Dissertação
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Universidade Federal Rural do Semi-Árido
Brasil
Centro de Ciências Agrárias - CCA
UFERSA
Programa de Pós-Graduação em Ciência Animal
Programa de Pós-Graduação: Não Informado pela instituição
Departamento: Não Informado pela instituição
País: Não Informado pela instituição
Palavras-chave em Português:
Link de acesso: https://repositorio.ufersa.edu.br/handle/prefix/5329
Resumo: The objective of this study was to evaluate the levels of phenols, total flavonoids, as well as the antioxidant, genoprotective and photoprotective activities of the red propolis ethanolic extract produced by Apis mellifera. Different concentrations of the extract were evaluated in vitro by spectrophotometry. The photoprotective effect of the extract was evaluated in vivo in 30 Wistar rats divided into three groups: Group I - the skin received no topical application of the extract and was not submitted to ultraviolet irradiation; Group II - the skin was not subjected to topical application of extract and were irradiated; Group III - skin underwent topical application of extract and were irradiated. The skin was evaluated macroscopically and the density of inflammatory cells, mast cells, necrotic cells and collagen fibers was quantified. The extract presented high levels of phenols and flavonoids with antioxidant and genoprotective capacity, protecting the skin from irradiation. In group II, erythemas, blisters and superficial crust were observed. No significant differences in mean values of mast cell density and collagen fibers did not differ between groups I and III. It was concluded that the ethanolic extract of red propolis exerted genoprotective and photoprotective effects by promoting satisfactory absorbances of ultraviolet radiation and was able to protect the skin from lesions induced by UVB irradiation.