Estudo comparativo do potencial antiinflamatório do diclofenaco de potássio e da hidrocortisona no Eritema Solar

Detalhes bibliográficos
Ano de defesa: 2007
Autor(a) principal: Sallum, Josineire Melo Costa
Orientador(a): Não Informado pela instituição
Banca de defesa: Não Informado pela instituição
Tipo de documento: Dissertação
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Não Informado pela instituição
Programa de Pós-Graduação: Não Informado pela instituição
Departamento: Não Informado pela instituição
País: Não Informado pela instituição
Palavras-chave em Português:
Link de acesso: http://www.repositorio.ufc.br/handle/riufc/5386
Resumo: There is evidence that UV radiation causes the release of mediators of inflammation molecules, these molecules responsible for triggering some of the biochemical reactions that cause erythema (L.Pons Gimier; JLParra Juez, 2005). Erythema is a physiological response very complex, composed of many variables that influence. Presents with a reddish skin, disappearing digital pressure. Erythema by flushing is due to arterial vasodilation active with increasing temperature, due to an inflammatory process, if the solar radiation. (Sampaio, 2000). The SPF is defined as the ratio between the amount of energy required to produce minimal erythema on the degree of protected skin with the sunscreen, and the amount of energy it takes the same level of erythema on unprotected skin. In this clinical study, double-blind, randomized, comparative, controlled aimed to evaluate the anti-inflammatory drug diclofenac and hydrocortisone treatment in preventive and remedial treatment of sunburn in healthy volunteers and fotipos skin I, II and III Pathak, 1983. Two groups of each 10 volunteers participated in this study: one group to determine the curative and preventive anti-inflammatory effects of Diclofenac diethylammonium, and the other, for determining the curative and preventive anti-inflammatory effect of Hydrocortisone on erythema. Four areas were demarcated in the infrascapular regions of each volunteer curative treatment and two control and two for the preventive treatment and control. As a source of ultraviolet light irradiation was used Arc Solar Simulator-Multisport. To read the erythema was used Mexameter equipment that quantifies the melanin and hemoglobin.