Fatores de risco para lesões cervicais e câncer cervical em mulheres com diagnóstico citológico de células escamosas atípicas, Maputo-Moçambique, 2013-2015

• Ano de defesa: 2017
• Autor(a) principal: Sitoe, Filomena Boaventura
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Palavras-chave em Português: Lesões do Pescoço; Câncer cervical; Biologia Celular; Histopatologia; Fatores de Risco
• Link de acesso: http://www.repositorio.ufc.br/handle/riufc/24966

Introduction: The diagnosis and screening of cervical lesions are of paramount importance. The standard screening method for cervical cancer and its precursor lesions is cytological examination using the Papanicolaou method. Objectives: To estimate the prevalence of low and high grade cervical lesions and cervical cancer in women with cytologic diagnosis of atypical squamous cells, to verify the influence of the etiological agents of diseases with the presence of cervical lesions and cervical cancer. Method: a cross-sectional study with a quantitative approach, retrospective data collection performed at the Department of Gynecology and Obstetrics, and at the Pathology Department of the Central Hospital of Maputo, Mozambique. We studied 358 medical records from January 2013 to December 2015 of women with atypical cytologic squamous cell diagnosis. The variables p <0.05 were considered statistically significant, and the frequency of diagnoses with their respective confidence intervals (95% CI) was calculated. The presence of the lesions and the degree of association between the dependent and independent variables were verified through the Pearson correlation coefficient and prevalence ratio (PR). Results: mean age was 38.1 years, median 36.6 and standard deviation 12.3. Age ranged from 17 to 71 years. The prevalence of cervical lesions was 153 cases (63%), 50 (32.7%) for <NIC2 + and 103 (67.3%) for CIN 2+. The risk factors associated with cervical lesions and cervical cancer were: age (40-49) (P = 0.001), profession (domestic) (P = 0.016), parity (+5) (P = 0.001), menopause = 0.001), HPV (P = 0.001) and Tricomonas vaginalis (P=0,001). Conclusion: The prevalence of high-grade cervical lesions in women with atypical squamous cell cytologic diagnosis was high. The risk factors associated with the most severe cervical lesions in patients with atypical squamous cell cytology were: parity age, occupation, menopause. The etiological agents of diseases that influenced the development of cervical lesions and cervical cancer were HPV and Tricomonas vaginalis.