Exames diagnósticos de lesões cervicais associadas ao papilomavírus humano

• Ano de defesa: 2016
• Autor(a) principal: Lima, Diego Jorge Maia
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Palavras-chave em Português: Neoplasias do Colo do Útero; Sensibilidade e Especificidade; Papillomaviridae; Lesões do Pescoço
• Link de acesso: http://www.repositorio.ufc.br/handle/riufc/61276

The purpose of the study was to verify the diagnostic accuracy of Oncology Cytology, Digital Cervicography and Visual Inspection with Acetic Acid for the diagnosis of cervical cancer precursor lesions, comparing the Their performances with the Polymerase Chain Reaction molecular test, considered the gold standard in the diagnosis of cervical lesion associated with Human Papillomavirus. An evaluation study carried out at the Lígia Barros Costa Natural Birth Center with thirty-five women who had already performed Oncology Cytology with Visual Inspection with Acetic Acid test in the Lígia Barros Costa Natural Birth Center and had a record in the Human Papillomavirus compatible lesion record. After searching the charts that met the inclusion criteria, the second phase in which the women were recruited through telephone contact to perform the interview and the Oncology Cytology, Digital Cervicography and Visual Inspection with Acetic Acid; And collection for papillomavirus DNA by Polymerase Chain Reaction technique with date and time marked. The Statistical Package for the Social Sciences, 20.0, was used for data storage and coding. Statistical analysis consisted of descriptive components and associations between the variables using the Pearson chi-square test and Student's t-test. The accuracy of the tests was verified by sensitivity, specificity, positive predictive value and negative predictive value. Ethical and legal aspects have been respected. It was found a mean age of 38.3 years, 54.3% (19) with partner, mean of 9.7 years of study, 88.6% (31) black / brown, 74.3% 22.9% (8) made use of alcohol, 17.1% (6) smoked, 45.7% (16) of overweight women, mean age of onset of sexual life of 17.4 74.3% (26) did not use the condom, 54.3% (19) with a history of STIs, 80% (28) performed the last gynecological cancer prevention in up to one year. The association between having a partner and HPV infection showed a statistically significant difference (p = 0.026). In Oncology Cytology, 11.4% (4) NIC I - LSIL, 2.9% (1) NIC II - HSIL and 5.7% (2) ASC-US. In , Visual Inspection with Acetic Acid 68.6% (24) were positive. Papillomavirus 16 and high risk were positive in 2.9% (1) and 11.4% (4), respectively. It can be stated that Digital Cervicography (judge 01) and Visual Inspection with Acetic Acid obtained greater sensitivity with 100% and 80%, respectively. The Oncology Cytology, in turn, obtained greater specificity with 89.5% and higher positive predictive value with 60% between the comparative exams. It was concluded that the accuracy of Papillomavirus testing varied widely, however, it was observed that CO showed to be a more consistent method of sensitivity, specificity, positive predictive value and negative predictive value.