Avaliação de controle metabólico, perfil de proteínas totais salivares e índices de placa e gengival em crianças com e sem diabetes mellitus tipo 1: um estudo caso-controle e prospectivo

• Ano de defesa: 2017
• Autor(a) principal: Ponte, Emerson Dias
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Palavras-chave em Português: Diabetes Mellitus Tipo 1; Criança; Saliva; Proteínas; Gengivite
• Link de acesso: http://www.repositorio.ufc.br/handle/riufc/22586

Diabetes mellitus type 1 (DM1) is characterized by a deficiency in insulin secretion, caused by the destruction of pancreatic beta cells and that has hyperglycemia as the main clinical finding. Periodontal diseases are characterized as the sixth complication of Diabetes Mellitus (DM). Poor long-term control of DM1 causes damage to the periodontium, and a chronic inflammation in the periodontal region may impair metabolic control of diabetes. Total protein concentration may also undergo changes due to DM1. Thus, the objective of this study was to longitudinally evaluate the total salivary protein profile, metabolic control, and plaque and gingival indices in children with DM1. A total of 39 participants were recruited for the DM1 (CDM1) and 56 patients to form the control group without DM1 (SDM1). Data collection took place in 3 pre-determined periods: initial consultation (T0) and after 6 and 12 months of initial consultation (T6, T12, respectively). Metabolic control was assessed by means of tests of fasting glucose, postprandial glycemia and glycated hemoglobin. The gingival condition was evaluated through plaque and gingival index. A sample of saliva was collected for each participant. They were then maintained, transported, centrifuged and stored appropriately for analysis. Total protein concentration was determined by the Bicinocinic Acid (BCA) method. There was an increase in post-prandial blood glucose levels (T0: 135.1, T6: 176.5; p = 0) in the total number of participants between the period T0 and T6; (T0: 031, T6: 0.24, p = 0.01) and also a decrease in the total protein concentration (T0: 1.06, T6: 0.91, p = 0 , 03). The CDM1 group (Mean: 0.32 ± 0.36) had plate indexes higher than the SDM1 group (Mean: 0.18 ± 0.14) in both the T6 period (p = 0.04) and the T12 period ( P = 0.02). In conclusion, diabetic patients have higher plaque indexes when compared to healthy patients. Comparing the period T0 and T6, it is suggested a relationship between the variables postprandial glycemia, plate index and total protein concentration, to be confirmed in future more specific analyzes.